Fields »
ABOUT
HELP
BLOG
POLR2F

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 POLR2F

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide F

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated), Nucleoli fibrillar center (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA000827 , CAB009882
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nucleoli (fibrillar center).

Main location

 Nucleus (validated), Nucleoli fibrillar center (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA000827 A-431 Nucleus
Nucleoli fibrillar center
HPA000827 U-2 OS Nucleus
Nucleoli fibrillar center
HPA000827 U-251 MG Nucleus
Nucleoli fibrillar center
CAB009882 A-431 Nucleus
Nucleoli fibrillar center
CAB009882 U-2 OS Nucleus
Nucleoli fibrillar center
CAB009882 U-251 MG Nucleus
Nucleoli fibrillar center

GENE INFORMATION

Gene name

 POLR2F (HGNC Symbol)

Synonyms

 HRBP14.4, RPB6

Description

 Polymerase (RNA) II (DNA directed) polypeptide F (HGNC Symbol)

Entrez gene summary

 This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 37952607 - 38041915

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100142 (version 83.38)

Entrez gene

 5435

UniProt

 P61218 (UniProt - Evidence at protein level)

neXtProt

 NX_P61218

Antibodypedia

 POLR2F antibodies

PROTEIN BROWSER
POLR2F-001
POLR2F-002
POLR2F-004
POLR2F-006
POLR2F-007
POLR2F-009
POLR2F-010
POLR2F-011
POLR2F-012
POLR2F-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2F-001
ENSP00000403852
ENST00000442738
P61218 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 127 aa
14.5 kDa 		No 0
POLR2F-002
ENSP00000475257
ENST00000460648
U3KPV3 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 74 aa
8.1 kDa 		No 0
POLR2F-004
ENSP00000475342
ENST00000488684
U3KQQ7 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 76 aa
8.4 kDa 		No 0
POLR2F-006
ENSP00000475343
ENST00000492213
U3KPY1 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 112 aa
12.7 kDa 		No 0
POLR2F-007
ENSP00000475707
ENST00000470701
U3KQB0 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005730 [nucleolus]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 122 aa
13.9 kDa 		No 0
POLR2F-009
ENSP00000385725
ENST00000407936
B0QYL9 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 158 aa
17.6 kDa 		No 0
POLR2F-010
ENSP00000384112
ENST00000405557
B0QYL8 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 126 aa
14.2 kDa 		No 0
POLR2F-011
ENSP00000332130
ENST00000333418
H0Y2U7 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 145 aa
15.1 kDa 		No 0
POLR2F-012
ENSP00000389307
ENST00000427034
H0Y439 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 93 aa
9.7 kDa 		No 0
POLR2F-013
ENSP00000476187
ENST00000606538
U3KQS8 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 98 aa
11.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.