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PICK1

GENERAL INFORMATION

Gene name

 PICK1

Gene description

 Protein interacting with PRKCA 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in endocrine tissues and CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA072674
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA072674

GENE INFORMATION

Gene name

 PICK1 (HGNC Symbol)

Synonyms

 dJ1039K5, MGC15204, PRKCABP

Description

 Protein interacting with PRKCA 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 38056311 - 38075701

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100151 (version 83.38)

Entrez gene

 9463

UniProt

 Q9NRD5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRD5

Antibodypedia

 PICK1 antibodies

PROTEIN BROWSER
PICK1-001
PICK1-002
PICK1-004
PICK1-005
PICK1-009
PICK1-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PICK1-001
ENSP00000385205
ENST00000404072
Q9NRD5 [Direct mapping]
PRKCA-binding protein
A0A024R1J5 [Target identity:100%; Query identity:100%]
Protein interacting with PRKCA 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002092 [positive regulation of receptor internalization]
GO:0005080 [protein kinase C binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006605 [protein targeting]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008022 [protein C-terminus binding]
GO:0015844 [monoamine transport]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0021782 [glial cell development]
GO:0030054 [cell junction]
GO:0030666 [endocytic vesicle membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0036294 [cellular response to decreased oxygen levels]
GO:0042149 [cellular response to glucose starvation]
GO:0042734 [presynaptic membrane]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043045 [DNA methylation involved in embryo development]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043113 [receptor clustering]
GO:0045161 [neuronal ion channel clustering]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0060292 [long term synaptic depression]
GO:0071933 [Arp2/3 complex binding]
GO:0097061 [dendritic spine organization]
GO:0097062 [dendritic spine maintenance]
GO:0097481 [neuronal postsynaptic density]
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 415 aa
46.6 kDa 		No 0
PICK1-002
ENSP00000349465
ENST00000356976
Q9NRD5 [Direct mapping]
PRKCA-binding protein
A0A024R1J5 [Target identity:100%; Query identity:100%]
Protein interacting with PRKCA 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002092 [positive regulation of receptor internalization]
GO:0005080 [protein kinase C binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008022 [protein C-terminus binding]
GO:0015844 [monoamine transport]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0021782 [glial cell development]
GO:0030054 [cell junction]
GO:0030666 [endocytic vesicle membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0036294 [cellular response to decreased oxygen levels]
GO:0042149 [cellular response to glucose starvation]
GO:0042734 [presynaptic membrane]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043045 [DNA methylation involved in embryo development]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043113 [receptor clustering]
GO:0045161 [neuronal ion channel clustering]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0060292 [long term synaptic depression]
GO:0071933 [Arp2/3 complex binding]
GO:0097061 [dendritic spine organization]
GO:0097062 [dendritic spine maintenance]
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 415 aa
46.6 kDa 		No 0
PICK1-004
ENSP00000416487
ENST00000445628
F6TII1 [Direct mapping]
PRKCA-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0005080 [protein kinase C binding]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043113 [receptor clustering]
GO:0045202 [synapse]
GO:0048167 [regulation of synaptic plasticity]
Show all
 38 aa
4.1 kDa 		No 0
PICK1-005
ENSP00000398141
ENST00000424694
F6V107 [Direct mapping]
PRKCA-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0019904 [protein domain specific binding]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043113 [receptor clustering]
GO:0045202 [synapse]
GO:0048167 [regulation of synaptic plasticity]
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 229 aa
25.1 kDa 		No 0
PICK1-009
ENSP00000397588
ENST00000435166
F6VY12 [Direct mapping]
PRKCA-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043113 [receptor clustering]
GO:0045202 [synapse]
GO:0048167 [regulation of synaptic plasticity]
Show all
 134 aa
14.4 kDa 		No 0
PICK1-016
ENSP00000410793
ENST00000437453
F6V3V1 [Direct mapping]
PRKCA-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043113 [receptor clustering]
GO:0045202 [synapse]
GO:0048167 [regulation of synaptic plasticity]
Show all
 130 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.