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A few cases of endometrial cancers showed moderate to strong cytoplasmic positivity in a fraction of tumor cells. A subset of cancer cells in a few cases of breast cancers showed moderate to strong cytoplasmic and membranous staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
CENPM (HGNC Symbol)
Synonyms
C22orf18, CENP-M, MGC861, Pane1
Description
Centromere protein M (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]