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TOMM22

GENERAL INFORMATION

Gene name

 TOMM22

Gene description

 Translocase of outer mitochondrial membrane 22 homolog (yeast)

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression in a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA003037
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003037

GENE INFORMATION

Gene name

 TOMM22 (HGNC Symbol)

Synonyms

 TOM22

Description

 Translocase of outer mitochondrial membrane 22 homolog (yeast) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 38681948 - 38685421

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100216 (version 83.38)

Entrez gene

 56993

UniProt

 Q9NS69 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NS69

Antibodypedia

 TOMM22 antibodies

PROTEIN BROWSER
TOMM22-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOMM22-001
ENSP00000216034
ENST00000216034
Q9NS69 [Direct mapping]
Mitochondrial import receptor subunit TOM22 homolog
Q549C5 [Target identity:100%; Query identity:100%]
HCG2010808, isoform CRA_a; MSTP065; cDNA, FLJ92357, Homo sapiens translocase of outer mitochondrial membrane 22 homolog(yeast) (TOMM22), mRNA
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005742 [mitochondrial outer membrane translocase complex]
GO:0005743 [mitochondrial inner membrane]
GO:0006626 [protein targeting to mitochondrion]
GO:0006886 [intracellular protein transport]
GO:0008320 [protein transmembrane transporter activity]
GO:0015266 [protein channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016236 [macroautophagy]
GO:0030150 [protein import into mitochondrial matrix]
GO:0031307 [integral component of mitochondrial outer membrane]
GO:0044267 [cellular protein metabolic process]
GO:0045040 [protein import into mitochondrial outer membrane]
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 142 aa
15.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.