Cell atlas - POLDIP3 - The Human Protein Atlas

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POLDIP3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytoplasmic bodies
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	POLDIP3
Gene description	Polymerase (DNA-directed), delta interacting protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the cytoplasmic bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (validated)
Additional location	In addition localized to the Cytoplasmic bodies (supported)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA018419 , HPA048790
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the cytoplasmic bodies.

Main location

Nuclear speckles (validated)

Additional location

Cytoplasmic bodies (supported)


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Antibody	Cell line	Location
HPA018419	A-431	Nuclear speckles
HPA018419	A-431	Cytoplasmic bodies
HPA018419	U-2 OS	Nuclear speckles
HPA018419	U-2 OS	Cytoplasmic bodies
HPA018419	U-251 MG	Nuclear speckles
HPA018419	U-251 MG	Cytoplasmic bodies
HPA048790	A-431	Nuclear speckles
HPA048790	U-2 OS	Nuclear speckles
HPA048790	U-251 MG	Nuclear speckles

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000041815 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048790	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	POLDIP3 (HGNC Symbol)
Synonyms	KIAA1649, PDIP46
Description	Polymerase (DNA-directed), delta interacting protein 3 (HGNC Symbol)
Entrez gene summary	This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	42583721 - 42614962
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100227 (version 83.38)
Entrez gene	84271
UniProt	Q9BY77 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY77
Antibodypedia	POLDIP3 antibodies

PROTEIN BROWSER

POLDIP3-001	POLDIP3-002	POLDIP3-201	POLDIP3-202	POLDIP3-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLDIP3-001 ENSP00000252115 ENST00000252115	Q9BY77 [Direct mapping] Polymerase delta-interacting protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000346 [transcription export complex] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016607 [nuclear speck] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0035145 [exon-exon junction complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0045727 [positive regulation of translation] Show all	421 aa 46.1 kDa	No	0
POLDIP3-002 ENSP00000252116 ENST00000348657	Q9BY77 [Direct mapping] Polymerase delta-interacting protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000346 [transcription export complex] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016607 [nuclear speck] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0035145 [exon-exon junction complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0045727 [positive regulation of translation] Show all	392 aa 42.9 kDa	No	0
POLDIP3-201 ENSP00000343060 ENST00000339677	Q6R954 [Direct mapping] Polymerase delta interacting protein 46; Polymerase delta-interacting protein 3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0043231 [intracellular membrane-bounded organelle] Show all	185 aa 20.1 kDa	No	0
POLDIP3-202 ENSP00000397927 ENST00000451060	F6VRR5 [Direct mapping] Polymerase delta-interacting protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	438 aa 48.1 kDa	No	0
POLDIP3-203 ENSP00000482500 ENST00000617178	Q8WUT1 [Direct mapping] POLDIP3 protein; Polymerase delta-interacting protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	229 aa 24.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.