Expression of SUN2 in cancer - Summary - The Human Protein Atlas

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SUN2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SUN2
Gene description	Sad1 and UNC84 domain containing 2
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear membrane expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA001209
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001209

GENE INFORMATION
Gene name	SUN2 (HGNC Symbol)
Synonyms	UNC84B
Description	Sad1 and UNC84 domain containing 2 (HGNC Symbol)
Entrez gene summary	SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	38734725 - 38794143
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100242 (version 83.38)
Entrez gene	25777
UniProt	Q9UH99 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UH99
Antibodypedia	SUN2 antibodies

PROTEIN BROWSER

SUN2-001	SUN2-002	SUN2-003	SUN2-004	SUN2-005	SUN2-006	SUN2-008	SUN2-009	SUN2-010	SUN2-011	SUN2-015	SUN2-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SUN2-001 ENSP00000385740 ENST00000405510	Q9UH99 [Direct mapping] SUN domain-containing protein 2 A0A024R1P7 [Target identity:100%; Query identity:100%] Unc-84 homolog B (C. elegans), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0006998 [nuclear envelope organization] GO:0007052 [mitotic spindle organization] GO:0007097 [nuclear migration] GO:0008017 [microtubule binding] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0030335 [positive regulation of cell migration] GO:0031022 [nuclear migration along microfilament] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0042802 [identical protein binding] GO:0043495 [protein anchor] GO:0051642 [centrosome localization] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	717 aa 80.3 kDa	No	2
SUN2-002 ENSP00000385616 ENST00000405018	Q9UH99 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0000794 [condensed nuclear chromosome] GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0006998 [nuclear envelope organization] GO:0007052 [mitotic spindle organization] GO:0007097 [nuclear migration] GO:0008017 [microtubule binding] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0030335 [positive regulation of cell migration] GO:0031022 [nuclear migration along microfilament] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0042802 [identical protein binding] GO:0043495 [protein anchor] GO:0051642 [centrosome localization] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	738 aa 82.5 kDa	No	2
SUN2-003 ENSP00000411615 ENST00000433561	B0QY66 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.1 kDa	No	0
SUN2-004 ENSP00000415588 ENST00000456894	B0QY64 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		228 aa 25.3 kDa	No	2
SUN2-005 ENSP00000414950 ENST00000452294	B0QY67 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 15.7 kDa	No	0
SUN2-006 ENSP00000393271 ENST00000439339	B0QY68 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.1 kDa	No	0
SUN2-008 ENSP00000408834 ENST00000420859	B0QY65 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.8 kDa	No	0
SUN2-009 ENSP00000406941 ENST00000438058	B0QY63 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	224 aa 25.4 kDa	No	1
SUN2-010 ENSP00000412928 ENST00000417332	B0QY69 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.6 kDa	No	0
SUN2-011 ENSP00000403694 ENST00000430185	H0Y686 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	143 aa 16.5 kDa	No	2
SUN2-015 ENSP00000390154 ENST00000455125	B0QY60 [Direct mapping] SUN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.8 kDa	No	0
SUN2-017 ENSP00000383992 ENST00000406622	Q9UH99 [Direct mapping] SUN domain-containing protein 2 A0A024R1P7 [Target identity:100%; Query identity:100%] Unc-84 homolog B (C. elegans), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0006998 [nuclear envelope organization] GO:0007052 [mitotic spindle organization] GO:0007097 [nuclear migration] GO:0008017 [microtubule binding] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0030335 [positive regulation of cell migration] GO:0031022 [nuclear migration along microfilament] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0042802 [identical protein binding] GO:0043495 [protein anchor] GO:0051642 [centrosome localization] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	717 aa 80.3 kDa	No	2

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