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DNAL4

GENERAL INFORMATION

Gene name

 DNAL4

Gene description

 Dynein, axonemal, light chain 4

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Expression in cilia and in cytoplasm in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003647
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DNAL4 (HGNC Symbol)

Synonyms

 dJ327J16, PIG27

Description

 Dynein, axonemal, light chain 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 38778508 - 38794198

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100246 (version 83.38)

Entrez gene

 10126

UniProt

 O96015 (UniProt - Evidence at protein level)

neXtProt

 NX_O96015

Antibodypedia

 DNAL4 antibodies

PROTEIN BROWSER
DNAL4-001
DNAL4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAL4-001
ENSP00000216068
ENST00000216068
O96015 [Direct mapping]
Dynein light chain 4, axonemal
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0030286 [dynein complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
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 105 aa
12 kDa 		No 0
DNAL4-002
ENSP00000385712
ENST00000406199
B0QXZ5 [Direct mapping]
Dynein light chain 4, axonemal
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005875 [microtubule associated complex]
GO:0007017 [microtubule-based process]
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 68 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.