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HMGXB4

GENERAL INFORMATION

Gene name

 HMGXB4

Gene description

 HMG box domain containing 4

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA000725
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HMGXB4 (HGNC Symbol)

Synonyms

 HMG2L1, THC211630

Description

 HMG box domain containing 4 (HGNC Symbol)

Entrez gene summary

 High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 35257452 - 35295807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100281 (version 83.38)

Entrez gene

 10042

UniProt

 Q9UGU5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UGU5

Antibodypedia

 HMGXB4 antibodies

PROTEIN BROWSER
HMGXB4-002
HMGXB4-003
HMGXB4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGXB4-002
ENSP00000216106
ENST00000216106
Q9UGU5 [Direct mapping]
HMG domain-containing protein 4
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008333 [endosome to lysosome transport]
GO:0016055 [Wnt signaling pathway]
GO:0016589 [NURF complex]
GO:0030178 [negative regulation of Wnt signaling pathway]
Show all
 601 aa
65.7 kDa 		No 0
HMGXB4-003
ENSP00000415500
ENST00000455359
B0QXZ8 [Direct mapping]
HMG domain-containing protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 284 aa
30.4 kDa 		No 0
HMGXB4-004
ENSP00000401658
ENST00000420166
B0QXZ9 [Direct mapping]
HMG domain-containing protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 285 aa
30.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.