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APOBEC3H

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GENERAL INFORMATION

Gene name

 APOBEC3H

Gene description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (Karpas-707, U-266/70)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 APOBEC3H (HGNC Symbol)

Synonyms

 ARP10

Description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 39097224 - 39104067

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100298 (version 83.38)

Entrez gene

 164668

UniProt

 Q6NTF7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6NTF7

Antibodypedia

 APOBEC3H antibodies

PROTEIN BROWSER
APOBEC3H-001
APOBEC3H-002
APOBEC3H-004
APOBEC3H-005
APOBEC3H-201
APOBEC3H-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOBEC3H-001
ENSP00000216123
ENST00000348946
Q6NTF7 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3H
B7TQM4 [Target identity:100%; Query identity:100%]
APOBEC3H
Show all
Predicted intracellular proteins
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
Show all
 182 aa
21.5 kDa 		No 0
APOBEC3H-002
ENSP00000385741
ENST00000401756
Q6NTF7 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3H
Show all
Predicted intracellular proteins
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
Show all
 200 aa
23.5 kDa 		No 0
APOBEC3H-004
ENSP00000482682
ENST00000613996
A0A087WZI3 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3H
Show all
Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
Show all
 154 aa
17.8 kDa 		No 0
APOBEC3H-005
ENSP00000411754
ENST00000442487
Q6NTF7 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3H
B7TQM3 [Target identity:100%; Query identity:100%]
APOBEC3H
Show all
Predicted intracellular proteins
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
Show all
 183 aa
21.7 kDa 		No 0
APOBEC3H-201
ENSP00000393520
ENST00000421988
Q6NTF7 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3H
Show all
Predicted intracellular proteins
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0045087 [innate immune response]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0048525 [negative regulation of viral process]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
Show all
 154 aa
17.8 kDa 		No 0
APOBEC3H-202
ENSP00000483689
ENST00000613677
M4W6S4 [Direct mapping]
Apolipoprotein B editing enzyme catalytic polypeptide-like 3H; DNA dC->dU-editing enzyme APOBEC-3H
Show all
Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
Show all
 200 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.