We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ACR
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACR

Gene description

Acrosin

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in spermatozoa.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA048687
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA048687

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues were negative. A rare case of colorectal cancer displayed moderate membranous staining.

GENE INFORMATION

Gene name

ACR

Synonyms

Description

Acrosin (HGNC Symbol)

Entrez gene summary

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.33

Chromosome location (bp)

50738196 - 50745334

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100312 (version 83.38)

Entrez gene

49

UniProt

P10323 (UniProt - Evidence at transcript level)

neXtProt

NX_P10323

Antibodypedia

ACR antibodies

PROTEIN BROWSER

ACR-001
ACR-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACR-001
ENSP00000216139
ENST00000216139
P10323 [Direct mapping]
Acrosin Acrosin light chain Acrosin heavy chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001669 [acrosomal vesicle]
GO:0002077 [acrosome matrix dispersal]
GO:0003677 [DNA binding]
GO:0004040 [amidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005798 [Golgi-associated vesicle]
GO:0006508 [proteolysis]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0007340 [acrosome reaction]
GO:0007341 [penetration of zona pellucida]
GO:0008144 [drug binding]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0032504 [multicellular organism reproduction]
GO:0042806 [fucose binding]
GO:0043159 [acrosomal matrix]
GO:0043234 [protein complex]
GO:0048545 [response to steroid hormone]
Show all
421 aa
45.8 kDa
Yes 0
ACR-003
ENSP00000435120
ENST00000529621
E9PLV5 [Direct mapping]
Acrosin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001669 [acrosomal vesicle]
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
212 aa
23.1 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.