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Malignant cells exhibited weak to moderate nuclear positivity in most cases. A few malignant gliomas, lymphomas and melanomas along with a few skin and testicular cancers were strongly stained. Most cases of liver, lung, pancreatic, gastric, endometrial and ovarian cancers were negative.
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]