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Hepatocellular carcinomas displayed moderate to strong cytoplasmic positivity. Colorectal, breast, prostate and female genital cancers as well as a few cases of pancreatic cancer showed moderate cytoplasmic positivity. Remaining cancer cells were weakly stained or negative.
Most cancer tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in several cases of testicular seminomas. Renal and liver cancers along with several lymphomas were negative.
GENE INFORMATION
Gene name
MTMR3 (HGNC Symbol)
Synonyms
FYVE-DSP1, KIAA0371, ZFYVE10
Description
Myotubularin related protein 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Q13615 [Direct mapping] Myotubularin-related protein 3
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q13615 [Direct mapping] Myotubularin-related protein 3 A0A024R1I2 [Target identity:100%; Query identity:100%] Myotubularin related protein 3, isoform CRA_d
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q13615 [Direct mapping] Myotubularin-related protein 3
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)