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TXN2

GENERAL INFORMATION

Gene name

 TXN2

Gene description

 Thioredoxin 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA000994 , CAB008681
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and prostate cancer (favourable).
Renal cancer p<0.001
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA000994
CAB008681

GENE INFORMATION

Gene name

 TXN2 (HGNC Symbol)

Synonyms

 MT-TRX

Description

 Thioredoxin 2 (HGNC Symbol)

Entrez gene summary

 This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 36467036 - 36482030

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100348 (version 83.38)

Entrez gene

 25828

UniProt

 Q99757 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99757

Antibodypedia

 TXN2 antibodies

PROTEIN BROWSER
TXN2-001
TXN2-002
TXN2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXN2-001
ENSP00000216185
ENST00000216185
Q99757 [Direct mapping]
Thioredoxin, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000103 [sulfate assimilation]
GO:0000302 [response to reactive oxygen species]
GO:0001666 [response to hypoxia]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0006979 [response to oxidative stress]
GO:0007584 [response to nutrient]
GO:0008113 [peptide-methionine (S)-S-oxide reductase activity]
GO:0009725 [response to hormone]
GO:0009749 [response to glucose]
GO:0014070 [response to organic cyclic compound]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0030425 [dendrite]
GO:0031669 [cellular response to nutrient levels]
GO:0032403 [protein complex binding]
GO:0033743 [peptide-methionine (R)-S-oxide reductase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0045454 [cell redox homeostasis]
GO:0048678 [response to axon injury]
GO:0055114 [oxidation-reduction process]
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 166 aa
18.4 kDa 		No 0
TXN2-002
ENSP00000469160
ENST00000416967
M0QXH0 [Direct mapping]
Thioredoxin, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000103 [sulfate assimilation]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
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 64 aa
7 kDa 		No 0
TXN2-005
ENSP00000385393
ENST00000403313
Q99757 [Direct mapping]
Thioredoxin, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0000302 [response to reactive oxygen species]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
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 166 aa
18.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.