We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate cytoplasmic positivity. Lymphomas, gliomas along with several melanomas, renal cell carcinomas and liver cancers were negative.
Most cancers exhibited moderate cytoplasmic positivity. A few colorectal, stomach along with rare breast, cervical, endometrial and pancreatic cancers showed strong positivity. Several renal cell carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
EIF3D (HGNC Symbol)
Synonyms
eIF3-p66, eIF3-zeta, eIF3d, EIF3S7
Description
Eukaryotic translation initiation factor 3, subunit D (HGNC Symbol)
Entrez gene summary
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]