Tissue expression of CSF2RB - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CSF2RB
Gene description	Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Protein class	CD markers Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CSF2RB (HGNC Symbol)
Synonyms	CD131, IL3RB, IL5RB
Description	Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	36913628 - 36940449
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100368 (version 83.38)
Entrez gene	1439
UniProt	P32927 (UniProt - Evidence at protein level)
neXtProt	NX_P32927
Antibodypedia	CSF2RB antibodies

PROTEIN BROWSER

CSF2RB-001	CSF2RB-002	CSF2RB-003	CSF2RB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSF2RB-001 ENSP00000384053 ENST00000403662	P32927 [Direct mapping] Cytokine receptor common subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004872 [receptor activity] GO:0004896 [cytokine receptor activity] GO:0004912 [interleukin-3 receptor activity] GO:0004914 [interleukin-5 receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007585 [respiratory gaseous exchange] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030526 [granulocyte macrophage colony-stimulating factor receptor complex] GO:0036016 [cellular response to interleukin-3] GO:0038043 [interleukin-5-mediated signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038156 [interleukin-3-mediated signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	897 aa 97.3 kDa	Yes	1
CSF2RB-002 ENSP00000385271 ENST00000406230	P32927 [Direct mapping] Cytokine receptor common subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004872 [receptor activity] GO:0004896 [cytokine receptor activity] GO:0004912 [interleukin-3 receptor activity] GO:0004914 [interleukin-5 receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007585 [respiratory gaseous exchange] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030526 [granulocyte macrophage colony-stimulating factor receptor complex] GO:0036016 [cellular response to interleukin-3] GO:0038043 [interleukin-5-mediated signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038156 [interleukin-3-mediated signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	903 aa 98 kDa	Yes	1
CSF2RB-003 ENSP00000393585 ENST00000421539	B0QY07 [Direct mapping] Cytokine receptor common subunit beta Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	229 aa 25.6 kDa	No	0
CSF2RB-201 ENSP00000262825 ENST00000262825	Q6NSJ8 [Direct mapping] CSF2RB protein; Cytokine receptor common subunit beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	889 aa 96.2 kDa	Yes	1