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Carcinoids, skin cancers and cases of renal cell carcinomas showed nuclear positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
RBX1 (HGNC Symbol)
Synonyms
BA554C12.1, RNF75, ROC1
Description
Ring-box 1, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]