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RANGAP1

GENERAL INFORMATION

Gene name

 RANGAP1

Gene description

 Ran GTPase activating protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in the nuclei, nuclear membrane and cytoplasm in all cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA050110 , CAB004293
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and stomach cancer (favourable).
Liver cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA050110
CAB004293

GENE INFORMATION

Gene name

 RANGAP1 (HGNC Symbol)

Synonyms

 Fug1, KIAA1835, SD

Description

 Ran GTPase activating protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 41245611 - 41286251

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100401 (version 83.38)

Entrez gene

 5905

UniProt

 P46060 (UniProt - Evidence at protein level)

neXtProt

 NX_P46060

Antibodypedia

 RANGAP1 antibodies

PROTEIN BROWSER
RANGAP1-001
RANGAP1-003
RANGAP1-004
RANGAP1-006
RANGAP1-007
RANGAP1-008
RANGAP1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RANGAP1-001
ENSP00000348577
ENST00000356244
P46060 [Direct mapping]
Ran GTPase-activating protein 1
A0A024R1U0 [Target identity:100%; Query identity:100%]
Ran GTPase activating protein 1, isoform CRA_d
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046826 [negative regulation of protein export from nucleus]
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 587 aa
63.5 kDa 		No 0
RANGAP1-003
ENSP00000385866
ENST00000405486
P46060 [Direct mapping]
Ran GTPase-activating protein 1
A0A024R1U0 [Target identity:100%; Query identity:100%]
Ran GTPase activating protein 1, isoform CRA_d
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046826 [negative regulation of protein export from nucleus]
Show all
 587 aa
63.5 kDa 		No 0
RANGAP1-004
ENSP00000401470
ENST00000455915
P46060 [Direct mapping]
Ran GTPase-activating protein 1
A0A024R1U0 [Target identity:100%; Query identity:100%]
Ran GTPase activating protein 1, isoform CRA_d
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008536 [Ran GTPase binding]
GO:0030425 [dendrite]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0044614 [nuclear pore cytoplasmic filaments]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048678 [response to axon injury]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0072686 [mitotic spindle]
GO:1904115 [axon cytoplasm]
GO:1904117 [cellular response to vasopressin]
GO:1990723 [cytoplasmic periphery of the nuclear pore complex]
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 587 aa
63.5 kDa 		No 0
RANGAP1-006
ENSP00000404842
ENST00000422838
B0QYT6 [Direct mapping]
Ran GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 37 aa
3.9 kDa 		No 0
RANGAP1-007
ENSP00000393407
ENST00000446258
H0Y4Q3 [Direct mapping]
Ran GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 253 aa
26.8 kDa 		No 0
RANGAP1-008
ENSP00000408743
ENST00000418067
B0QYT5 [Direct mapping]
Ran GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
Show all
 100 aa
10.9 kDa 		No 0
RANGAP1-009
ENSP00000394787
ENST00000452543
B0QYT4 [Direct mapping]
Ran GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031965 [nuclear membrane]
GO:0043547 [positive regulation of GTPase activity]
Show all
 133 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.