Expression of ABHD4 in cancer - Summary - The Human Protein Atlas

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ABHD4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABHD4
Gene description	Abhydrolase domain containing 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA000600
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000600

GENE INFORMATION
Gene name	ABHD4 (HGNC Symbol)
Synonyms	FLJ12816
Description	Abhydrolase domain containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	22598237 - 22613215
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100439 (version 83.38)
Entrez gene	63874
UniProt	Q8TB40 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TB40
Antibodypedia	ABHD4 antibodies

PROTEIN BROWSER

ABHD4-001	ABHD4-006	ABHD4-008	ABHD4-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD4-001 ENSP00000414558 ENST00000428304	Q8TB40 [Direct mapping] Abhydrolase domain-containing protein 4 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0016042 [lipid catabolic process] GO:0019915 [lipid storage] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0052689 [carboxylic ester hydrolase activity] GO:0055088 [lipid homeostasis] Show all	342 aa 38.8 kDa	No	0
ABHD4-006 ENSP00000437385 ENST00000542041	F5H6T0 [Direct mapping] Abhydrolase domain-containing protein 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.1 kDa	No	0
ABHD4-008 ENSP00000444550 ENST00000545034	F5GZC9 [Direct mapping] Abhydrolase domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.2 kDa	No	0
ABHD4-012 ENSP00000216327 ENST00000216327	J3KMW0 [Direct mapping] Abhydrolase domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.