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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CTSG
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CTSG

Gene description

Cathepsin G

Protein class

Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (THP-1)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subsets of lymphoid and hematopoietic cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA047737 , CAB000110
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PROGNOSTIC SUMMARY

Prognostic marker in head and neck cancer (favourable) and urothelial cancer (unfavourable).
Head and neck cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA047737
CAB000110

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All malignancies were negative.

GENE INFORMATION

Gene name

CTSG (HGNC Symbol)

Synonyms

CG

Description

Cathepsin G (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

Chromosome

14

Cytoband

q12

Chromosome location (bp)

24573522 - 24576260

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100448 (version 83.38)

Entrez gene

1511

UniProt

P08311 (UniProt - Evidence at protein level)

neXtProt

NX_P08311

Antibodypedia

CTSG antibodies

PROTEIN BROWSER

CTSG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSG-001
ENSP00000216336
ENST00000216336
P08311 [Direct mapping]
Cathepsin G
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002003 [angiotensin maturation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006508 [proteolysis]
GO:0006955 [immune response]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0009986 [cell surface]
GO:0016485 [protein processing]
GO:0022617 [extracellular matrix disassembly]
GO:0030141 [secretory granule]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0032496 [response to lipopolysaccharide]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0044267 [cellular protein metabolic process]
GO:0050778 [positive regulation of immune response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050832 [defense response to fungus]
GO:0070062 [extracellular exosome]
GO:0070946 [neutrophil mediated killing of gram-positive bacterium]
Show all
255 aa
28.8 kDa
Yes 0

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