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POLE2

GENERAL INFORMATION

Gene name

 POLE2

Gene description

 Polymerase (DNA directed), epsilon 2, accessory subunit

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues, including lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Cytoplasmic staining was viewed as off target and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA027555
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027555

GENE INFORMATION

Gene name

 POLE2 (HGNC Symbol)

Synonyms

 DPE2

Description

 Polymerase (DNA directed), epsilon 2, accessory subunit (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q21.3

Chromosome location (bp)

 49643555 - 49688422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100479 (version 83.38)

Entrez gene

 5427

UniProt

 P56282 (UniProt - Evidence at protein level)

neXtProt

 NX_P56282

Antibodypedia

 POLE2 antibodies

PROTEIN BROWSER
POLE2-001
POLE2-002
POLE2-008
POLE2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLE2-001
ENSP00000216367
ENST00000216367
P56282 [Direct mapping]
DNA polymerase epsilon subunit 2
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006281 [DNA repair]
GO:0008622 [epsilon DNA polymerase complex]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0042276 [error-prone translesion synthesis]
GO:0043231 [intracellular membrane-bounded organelle]
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 527 aa
59.5 kDa 		No 0
POLE2-002
ENSP00000446313
ENST00000539565
P56282 [Direct mapping]
DNA polymerase epsilon subunit 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006281 [DNA repair]
GO:0008622 [epsilon DNA polymerase complex]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0042276 [error-prone translesion synthesis]
GO:0043231 [intracellular membrane-bounded organelle]
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 501 aa
56.4 kDa 		No 0
POLE2-008
ENSP00000475468
ENST00000553805
U3KQ22 [Direct mapping]
DNA polymerase epsilon subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006261 [DNA-dependent DNA replication]
GO:0042276 [error-prone translesion synthesis]
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 96 aa
10.9 kDa 		No 0
POLE2-012
ENSP00000451621
ENST00000554396
P56282 [Direct mapping]
DNA polymerase epsilon subunit 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006281 [DNA repair]
GO:0008622 [epsilon DNA polymerase complex]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0042276 [error-prone translesion synthesis]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 502 aa
56.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.