Expression of NIN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NIN
Gene description	Ninein (GSK3B interacting protein)
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types. Additional distinct perinuclear expression mainly in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA005939
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005939

GENE INFORMATION
Gene name	NIN
Synonyms
Description	Ninein (GSK3B interacting protein) (HGNC Symbol)
Entrez gene summary	This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q22.1
Chromosome location (bp)	50719763 - 50831121
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100503 (version 83.38)
Entrez gene	51199
UniProt	Q8N4C6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4C6
Antibodypedia	NIN antibodies

PROTEIN BROWSER

NIN-004	NIN-008	NIN-010	NIN-012	NIN-016	NIN-017	NIN-018	NIN-019	NIN-201	NIN-202	NIN-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NIN-004 ENSP00000431826 ENST00000496749	E9PJH9 [Direct mapping] Ninein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005813 [centrosome] GO:0034454 [microtubule anchoring at centrosome] Show all	101 aa 11.6 kDa	No	0
NIN-008 ENSP00000398641 ENST00000453401	H7C162 [Direct mapping] Ninein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0034454 [microtubule anchoring at centrosome] Show all	396 aa 45.3 kDa	No	0
NIN-010 ENSP00000371474 ENST00000382043	Q8N4C6 [Direct mapping] Ninein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0051642 [centrosome localization] Show all	1377 aa 160.1 kDa	No	0
NIN-012 ENSP00000473530 ENST00000486950	R4GN85 [Direct mapping] Ninein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0034454 [microtubule anchoring at centrosome] Show all	116 aa 13.1 kDa	No	0
NIN-016 ENSP00000371472 ENST00000382041	Q8N4C6 [Direct mapping] Ninein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005874 [microtubule] GO:0034454 [microtubule anchoring at centrosome] GO:0051642 [centrosome localization] GO:0090222 [centrosome-templated microtubule nucleation] Show all	2090 aa 243.2 kDa	No	0
NIN-017 ENSP00000436092 ENST00000530997	Q8N4C6 [Direct mapping] Ninein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0051642 [centrosome localization] Show all	2133 aa 248.2 kDa	No	0
NIN-018 ENSP00000433717 ENST00000530853	H0YDJ4 [Direct mapping] Ninein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0034454 [microtubule anchoring at centrosome] Show all	1537 aa 179.4 kDa	No	0
NIN-019 ENSP00000374519 ENST00000389869	H9KV85 [Direct mapping] Ninein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0034454 [microtubule anchoring at centrosome] Show all	1581 aa 184.5 kDa	No	0
NIN-201 ENSP00000245441 ENST00000245441	Q8N4C6 [Direct mapping] Ninein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0051642 [centrosome localization] Show all	2133 aa 248.2 kDa	No	0
NIN-202 ENSP00000324210 ENST00000324330	Q8N4C6 [Direct mapping] Ninein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0051642 [centrosome localization] Show all	1377 aa 160.1 kDa	No	0
NIN-203 ENSP00000412391 ENST00000453196	C9J066 [Direct mapping] Ninein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005730 [nucleolus] GO:0005813 [centrosome] GO:0034454 [microtubule anchoring at centrosome] Show all	2046 aa 238.2 kDa	No	0