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CDKN3

GENERAL INFORMATION

Gene name

 CDKN3

Gene description

 Cyclin-dependent kinase inhibitor 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Lung cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CDKN3 (HGNC Symbol)

Synonyms

 CDI1, KAP

Description

 Cyclin-dependent kinase inhibitor 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

 14

Cytoband

 q22.2

Chromosome location (bp)

 54396849 - 54420218

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100526 (version 83.38)

Entrez gene

 1033

UniProt

 Q16667 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16667

Antibodypedia

 CDKN3 antibodies

PROTEIN BROWSER
CDKN3-001
CDKN3-002
CDKN3-003
CDKN3-004
CDKN3-009
CDKN3-010
CDKN3-201
CDKN3-202
CDKN3-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDKN3-001
ENSP00000335357
ENST00000335183
Q16667 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0007050 [cell cycle arrest]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
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 212 aa
23.8 kDa 		No 0
CDKN3-002
ENSP00000396451
ENST00000458126
H7C0S3 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0007049 [cell cycle]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 211 aa
23.7 kDa 		No 0
CDKN3-003
ENSP00000415333
ENST00000442975
Q16667 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0007050 [cell cycle arrest]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 172 aa
19.4 kDa 		No 0
CDKN3-004
ENSP00000445572
ENST00000541304
F5H232 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 146 aa
16.5 kDa 		No 0
CDKN3-009
ENSP00000440404
ENST00000543789
G3V1K6 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 148 aa
16.6 kDa 		No 0
CDKN3-010
ENSP00000450711
ENST00000556102
G3V2J7 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0007049 [cell cycle]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 203 aa
22.5 kDa 		No 0
CDKN3-201
ENSP00000378944
ENST00000395577
F8WD24 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005737 [cytoplasm]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 166 aa
18.7 kDa 		No 0
CDKN3-202
ENSP00000480289
ENST00000611205
A0A087WWK3 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0007049 [cell cycle]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 207 aa
23.1 kDa 		No 0
CDKN3-203
ENSP00000479875
ENST00000620759
A0A087WW25 [Direct mapping]
Cyclin-dependent kinase inhibitor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 35 aa
4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.