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VTI1B

GENERAL INFORMATION

Gene name

 VTI1B

Gene description

 Vesicle transport through interaction with t-SNAREs 1B

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA044121 , HPA060118
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044121
HPA060118

GENE INFORMATION

Gene name

 VTI1B (HGNC Symbol)

Synonyms

 VTI2

Description

 Vesicle transport through interaction with t-SNAREs 1B (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q24.1

Chromosome location (bp)

 67647075 - 67674831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100568 (version 83.38)

Entrez gene

 10490

UniProt

 Q9UEU0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UEU0

Antibodypedia

 VTI1B antibodies

PROTEIN BROWSER
VTI1B-001
VTI1B-005
VTI1B-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VTI1B-001
ENSP00000450731
ENST00000554659
Q9UEU0 [Direct mapping]
Vesicle transport through interaction with t-SNAREs homolog 1B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006623 [protein targeting to vacuole]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0006896 [Golgi to vacuole transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0008021 [synaptic vesicle]
GO:0008283 [cell proliferation]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019869 [chloride channel inhibitor activity]
GO:0031201 [SNARE complex]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048280 [vesicle fusion with Golgi apparatus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0061025 [membrane fusion]
GO:1903076 [regulation of protein localization to plasma membrane]
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 232 aa
26.7 kDa 		No 1
VTI1B-005
ENSP00000451759
ENST00000556461
H0YJL5 [Direct mapping]
Vesicle transport through interaction with t-SNAREs homolog 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005484 [SNAP receptor activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006623 [protein targeting to vacuole]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0006896 [Golgi to vacuole transport]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0031201 [SNARE complex]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0048280 [vesicle fusion with Golgi apparatus]
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 103 aa
11.6 kDa 		No 0
VTI1B-006
ENSP00000451661
ENST00000554636
H0YJJ5 [Direct mapping]
Vesicle transport through interaction with t-SNAREs homolog 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006623 [protein targeting to vacuole]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0006896 [Golgi to vacuole transport]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0031201 [SNARE complex]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0048280 [vesicle fusion with Golgi apparatus]
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 128 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.