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GSTZ1

GENERAL INFORMATION

Gene name

 GSTZ1

Gene description

 Glutathione S-transferase zeta 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004701
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), ovarian cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004701

GENE INFORMATION

Gene name

 GSTZ1 (HGNC Symbol)

Synonyms

 GSTZ1-1, MAAI, MAI

Description

 Glutathione S-transferase zeta 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 77320884 - 77331597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100577 (version 83.38)

Entrez gene

 2954

UniProt

 O43708 (UniProt - Evidence at protein level)

neXtProt

 NX_O43708

Antibodypedia

 GSTZ1 antibodies

PROTEIN BROWSER
«
GSTZ1-001
GSTZ1-002
GSTZ1-005
GSTZ1-007
GSTZ1-008
GSTZ1-009
GSTZ1-012
GSTZ1-013
GSTZ1-015
GSTZ1-017
GSTZ1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSTZ1-001
ENSP00000216465
ENST00000216465
A0A0C4DFM0 [Direct mapping]
Glutathione transferase zeta 1 (Maleylacetoacetate isomerase), isoform CRA_c; Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016740 [transferase activity]
GO:0016853 [isomerase activity]
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 216 aa
24.1 kDa 		No 0
GSTZ1-002
ENSP00000354959
ENST00000361389
O43708 [Direct mapping]
Maleylacetoacetate isomerase
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Enzymes
   ENZYME proteins
   Transferases
   Isomerase
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006559 [L-phenylalanine catabolic process]
GO:0006572 [tyrosine catabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016034 [maleylacetoacetate isomerase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:1901687 [glutathione derivative biosynthetic process]
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 161 aa
17.9 kDa 		No 0
GSTZ1-005
ENSP00000451976
ENST00000553586
G3V4T6 [Direct mapping]
Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0009072 [aromatic amino acid family metabolic process]
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 217 aa
24.2 kDa 		No 0
GSTZ1-007
ENSP00000452498
ENST00000554279
G3V5T0 [Direct mapping]
Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0009072 [aromatic amino acid family metabolic process]
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 202 aa
22.6 kDa 		No 0
GSTZ1-008
ENSP00000451927
ENST00000557639
O43708 [Direct mapping]
Maleylacetoacetate isomerase
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Enzymes
   ENZYME proteins
   Transferases
   Isomerase
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006559 [L-phenylalanine catabolic process]
GO:0006572 [tyrosine catabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016034 [maleylacetoacetate isomerase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 161 aa
17.9 kDa 		No 0
GSTZ1-009
ENSP00000314404
ENST00000349555
A0A0A0MR33 [Direct mapping]
Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 174 aa
19.4 kDa 		No 0
GSTZ1-012
ENSP00000450487
ENST00000556627
G3V267 [Direct mapping]
Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0009072 [aromatic amino acid family metabolic process]
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 189 aa
21.1 kDa 		No 0
GSTZ1-013
ENSP00000451150
ENST00000557053
G3V3B9 [Direct mapping]
Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 119 aa
13.2 kDa 		No 0
GSTZ1-015
ENSP00000452531
ENST00000554846
G3V5U6 [Direct mapping]
Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 59 aa
6.6 kDa 		No 0
GSTZ1-017
ENSP00000452346
ENST00000555583
G3V5G8 [Direct mapping]
Maleylacetoacetate isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 38 aa
4.4 kDa 		No 0
GSTZ1-201
ENSP00000377335
ENST00000393734
O43708 [Direct mapping]
Maleylacetoacetate isomerase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Isomerase
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006559 [L-phenylalanine catabolic process]
GO:0006572 [tyrosine catabolic process]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009072 [aromatic amino acid family metabolic process]
GO:0016034 [maleylacetoacetate isomerase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 161 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.