Expression of ISM2 in cancer - Summary - The Human Protein Atlas

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ISM2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ISM2
Gene description	Isthmin 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA039314 , HPA039742
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039314	HPA039742

GENE INFORMATION
Gene name	ISM2 (HGNC Symbol)
Synonyms	FLJ32147, TAIL1, THSD3
Description	Isthmin 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	77474394 - 77498850
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100593 (version 83.38)
Entrez gene	145501
UniProt	Q6H9L7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6H9L7
Antibodypedia	ISM2 antibodies

PROTEIN BROWSER

ISM2-001	ISM2-003	ISM2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ISM2-001 ENSP00000341490 ENST00000342219	Q6H9L7 [Direct mapping] Isthmin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] Show all	571 aa 63.9 kDa	Yes	0
ISM2-003 ENSP00000420452 ENST00000493585	Q6H9L7 [Direct mapping] Isthmin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] Show all	292 aa 31.3 kDa	Yes	0
ISM2-008 ENSP00000450791 ENST00000554801	G3V2Q2 [Direct mapping] Isthmin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		185 aa 20.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.