Expression of LGMN in cancer - Summary - The Human Protein Atlas

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LGMN

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LGMN
Gene description	Legumain
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RPMI-8226, U-266/70)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA001426
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001426

GENE INFORMATION
Gene name	LGMN (HGNC Symbol)
Synonyms	LGMN1, PRSC1
Description	Legumain (HGNC Symbol)
Entrez gene summary	This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.12
Chromosome location (bp)	92703807 - 92748702
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100600 (version 83.38)
Entrez gene	5641
UniProt	Q99538 (UniProt - Evidence at protein level)
neXtProt	NX_Q99538
Antibodypedia	LGMN antibodies

PROTEIN BROWSER

LGMN-001	LGMN-002	LGMN-004	LGMN-005	LGMN-009	LGMN-010	LGMN-011	LGMN-012	LGMN-015	LGMN-018	LGMN-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGMN-001 ENSP00000334052 ENST00000334869	Q99538 [Direct mapping] Legumain Q53XC6 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DI011YN22 of Placenta of Homo sapiens (human); Legumain, isoform CRA_a; cDNA FLJ78453, highly similar to Homo sapiens legumain (LGMN), transcript variant 2, mRNA Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0003014 [renal system process] GO:0004197 [cysteine-type endopeptidase activity] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0006624 [vacuolar protein processing] GO:0008202 [steroid metabolic process] GO:0008233 [peptidase activity] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0032801 [receptor catabolic process] GO:0042359 [vitamin D metabolic process] GO:0043202 [lysosomal lumen] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular exosome] GO:1901185 [negative regulation of ERBB signaling pathway] Show all	433 aa 49.4 kDa	Yes	0
LGMN-002 ENSP00000452572 ENST00000557434	Q99538 [Direct mapping] Legumain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0003014 [renal system process] GO:0004197 [cysteine-type endopeptidase activity] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0006624 [vacuolar protein processing] GO:0008202 [steroid metabolic process] GO:0008233 [peptidase activity] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0032801 [receptor catabolic process] GO:0042359 [vitamin D metabolic process] GO:0043202 [lysosomal lumen] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular exosome] GO:1901185 [negative regulation of ERBB signaling pathway] Show all	376 aa 42.9 kDa	Yes	0
LGMN-004 ENSP00000451861 ENST00000555699	Q99538 [Direct mapping] Legumain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0003014 [renal system process] GO:0004197 [cysteine-type endopeptidase activity] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0006624 [vacuolar protein processing] GO:0008202 [steroid metabolic process] GO:0008233 [peptidase activity] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0032801 [receptor catabolic process] GO:0042359 [vitamin D metabolic process] GO:0043202 [lysosomal lumen] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular exosome] GO:1901185 [negative regulation of ERBB signaling pathway] Show all	372 aa 42 kDa	Yes	0
LGMN-005 ENSP00000376911 ENST00000393218	Q99538 [Direct mapping] Legumain Q53XC6 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DI011YN22 of Placenta of Homo sapiens (human); Legumain, isoform CRA_a; cDNA FLJ78453, highly similar to Homo sapiens legumain (LGMN), transcript variant 2, mRNA Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0003014 [renal system process] GO:0004197 [cysteine-type endopeptidase activity] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0006508 [proteolysis] GO:0006624 [vacuolar protein processing] GO:0008202 [steroid metabolic process] GO:0008233 [peptidase activity] GO:0010447 [response to acidic pH] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0032801 [receptor catabolic process] GO:0040015 [negative regulation of multicellular organism growth] GO:0042359 [vitamin D metabolic process] GO:0043202 [lysosomal lumen] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045177 [apical part of cell] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular exosome] GO:1901185 [negative regulation of ERBB signaling pathway] Show all	433 aa 49.4 kDa	Yes	0
LGMN-009 ENSP00000451797 ENST00000553371	A0A0E3D6N4 [Direct mapping] Legumain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008233 [peptidase activity] Show all	57 aa 6.3 kDa	Yes	0
LGMN-010 ENSP00000452268 ENST00000554080	G3V5B2 [Direct mapping] Legumain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008233 [peptidase activity] Show all	58 aa 6.4 kDa	Yes	0
LGMN-011 ENSP00000450677 ENST00000554397	G3V4P5 [Direct mapping] Legumain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008233 [peptidase activity] Show all	78 aa 8.7 kDa	Yes	0
LGMN-012 ENSP00000450854 ENST00000553802	G3V2T4 [Direct mapping] Legumain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008233 [peptidase activity] Show all	135 aa 14.6 kDa	Yes	0
LGMN-015 ENSP00000451916 ENST00000554919	G3V4P5 [Direct mapping] Legumain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008233 [peptidase activity] Show all	78 aa 8.7 kDa	Yes	0
LGMN-018 ENSP00000450619 ENST00000553918	G3V2E9 [Direct mapping] Legumain Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		19 aa 2 kDa	No	0
LGMN-020 ENSP00000451854 ENST00000555169	H0YJN9 [Direct mapping] Legumain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008233 [peptidase activity] Show all	91 aa 9.7 kDa	No	0

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The Human Protein Atlas

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