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ALKBH1

GENERAL INFORMATION

Gene name

 ALKBH1

Gene description

 AlkB homolog 1, histone H2A dioxygenase

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA044087
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044087

GENE INFORMATION

Gene name

 ALKBH1 (HGNC Symbol)

Synonyms

 ABH, alkB, ALKBH, hABH

Description

 AlkB homolog 1, histone H2A dioxygenase (HGNC Symbol)

Entrez gene summary

 This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 77672404 - 77708020

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100601 (version 83.38)

Entrez gene

 8846

UniProt

 Q13686 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13686

Antibodypedia

 ALKBH1 antibodies

PROTEIN BROWSER
ALKBH1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALKBH1-001
ENSP00000216489
ENST00000216489
Q13686 [Direct mapping]
Alkylated DNA repair protein alkB homolog 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Lyases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0016491 [oxidoreductase activity]
GO:0042245 [RNA repair]
GO:0055114 [oxidation-reduction process]
GO:0070579 [methylcytosine dioxygenase activity]
GO:0070989 [oxidative demethylation]
GO:0080111 [DNA demethylation]
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 389 aa
43.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.