Expression of DHRS7 in cancer - Summary - The Human Protein Atlas

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DHRS7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DHRS7
Gene description	Dehydrogenase/reductase (SDR family) member 7
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA031121
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (unfavourable), breast cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Breast cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031121

GENE INFORMATION
Gene name	DHRS7 (HGNC Symbol)
Synonyms	retDSR4, SDR34C1
Description	Dehydrogenase/reductase (SDR family) member 7 (HGNC Symbol)
Entrez gene summary	Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]
Chromosome	14
Cytoband	q23.1
Chromosome location (bp)	60144120 - 60169856
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100612 (version 83.38)
Entrez gene	51635
UniProt	Q9Y394 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y394
Antibodypedia	DHRS7 antibodies

PROTEIN BROWSER

DHRS7-001	DHRS7-002	DHRS7-003	DHRS7-004	DHRS7-008	DHRS7-010	DHRS7-201	DHRS7-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHRS7-001 ENSP00000216500 ENST00000216500	Q9Y394 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	339 aa 38.3 kDa	No	0
DHRS7-002 ENSP00000442993 ENST00000536410	Q9Y394 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	289 aa 32.3 kDa	No	0
DHRS7-003 ENSP00000450899 ENST00000554101	H0YJ66 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	399 aa 44.7 kDa	Yes	0
DHRS7-004 ENSP00000452375 ENST00000557326	G3V5J0 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 7.1 kDa	No	0
DHRS7-008 ENSP00000451321 ENST00000557137	H0YJE4 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	160 aa 17.9 kDa	No	0
DHRS7-010 ENSP00000452026 ENST00000557751	H0YJR8 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	212 aa 23.4 kDa	No	0
DHRS7-201 ENSP00000451882 ENST00000557185	Q9Y394 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	339 aa 38.3 kDa	No	0
DHRS7-202 ENSP00000483770 ENST00000611054	A0A087X0Z7 [Direct mapping] Dehydrogenase/reductase SDR family member 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	376 aa 42.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.