Expression of TCL1A in cancer - Summary

GENERAL INFORMATION
Gene name	TCL1A
Gene description	T-cell leukemia/lymphoma 1A
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Group enriched (Daudi, REH, U-698)
HPA (normal tissue):	Tissue enhanced (lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct nuclear and cytoplasmic expression in subsets of immune cells in the mantle zone.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA016604 , CAB004045
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA016604	CAB004045

GENE INFORMATION
Gene name	TCL1A (HGNC Symbol)
Synonyms	TCL1
Description	T-cell leukemia/lymphoma 1A (HGNC Symbol)
Entrez gene summary	Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	95709967 - 95714196
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100721 (version 83.38)
Entrez gene	8115
UniProt	P56279 (UniProt - Evidence at protein level)
neXtProt	NX_P56279
Antibodypedia	TCL1A antibodies

PROTEIN BROWSER

TCL1A-001	TCL1A-002	TCL1A-005	TCL1A-007	TCL1A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TCL1A-001 ENSP00000451506 ENST00000554012	P56279 [Direct mapping] T-cell leukemia/lymphoma protein 1A A0A024R6G5 [Target identity:100%; Query identity:100%] T-cell leukemia/lymphoma 1A, isoform CRA_b Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0007275 [multicellular organismal development] Show all	114 aa 13.5 kDa	No	0
TCL1A-002 ENSP00000450496 ENST00000555202	P56279 [Direct mapping] T-cell leukemia/lymphoma protein 1A A0A024R6G5 [Target identity:100%; Query identity:100%] T-cell leukemia/lymphoma 1A, isoform CRA_b Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0007275 [multicellular organismal development] Show all	114 aa 13.5 kDa	No	0
TCL1A-005 ENSP00000450701 ENST00000556450	P56279 [Direct mapping] T-cell leukemia/lymphoma protein 1A A0A024R6G5 [Target identity:100%; Query identity:100%] T-cell leukemia/lymphoma 1A, isoform CRA_b Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0007275 [multicellular organismal development] Show all	114 aa 13.5 kDa	No	0
TCL1A-007 ENSP00000452028 ENST00000557043	H0YJR9 [Direct mapping] T-cell leukemia/lymphoma protein 1A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6.2 kDa	No	0
TCL1A-201 ENSP00000385036 ENST00000402399	P56279 [Direct mapping] T-cell leukemia/lymphoma protein 1A A0A024R6G5 [Target identity:100%; Query identity:100%] T-cell leukemia/lymphoma 1A, isoform CRA_b Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005938 [cell cortex] GO:0007275 [multicellular organismal development] GO:0010629 [negative regulation of gene expression] GO:0019827 [stem cell population maintenance] GO:0045120 [pronucleus] GO:2000036 [regulation of stem cell population maintenance] Show all	114 aa 13.5 kDa	No	0