Expression of GSKIP in cancer - Summary - The Human Protein Atlas

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GSKIP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GSKIP
Gene description	GSK3B interacting protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA043054 , HPA046782
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043054	HPA046782

GENE INFORMATION
Gene name	GSKIP (HGNC Symbol)
Synonyms	C14orf129
Description	GSK3B interacting protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	96363452 - 96387288
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100744 (version 83.38)
Entrez gene	51527
UniProt	Q9P0R6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0R6
Antibodypedia	GSKIP antibodies

PROTEIN BROWSER

GSKIP-001	GSKIP-002	GSKIP-003	GSKIP-005	GSKIP-006	GSKIP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GSKIP-001 ENSP00000451188 ENST00000556095	Q9P0R6 [Direct mapping] GSK3-beta interaction protein A0A024R6P6 [Target identity:100%; Query identity:100%] Chromosome 14 open reading frame 129, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	139 aa 15.6 kDa	No	0
GSKIP-002 ENSP00000450420 ENST00000555181	Q9P0R6 [Direct mapping] GSK3-beta interaction protein A0A024R6P6 [Target identity:100%; Query identity:100%] Chromosome 14 open reading frame 129, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	139 aa 15.6 kDa	No	0
GSKIP-003 ENSP00000451072 ENST00000553699	G3V368 [Direct mapping] GSK3-beta interaction protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.8 kDa	No	0
GSKIP-005 ENSP00000451384 ENST00000554182	Q9P0R6 [Direct mapping] GSK3-beta interaction protein A0A024R6P6 [Target identity:100%; Query identity:100%] Chromosome 14 open reading frame 129, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	139 aa 15.6 kDa	No	0
GSKIP-006 ENSP00000451820 ENST00000555757	G3V4I5 [Direct mapping] GSK3-beta interaction protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.3 kDa	No	0
GSKIP-201 ENSP00000412315 ENST00000438650	Q9P0R6 [Direct mapping] GSK3-beta interaction protein A0A024R6P6 [Target identity:100%; Query identity:100%] Chromosome 14 open reading frame 129, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	139 aa 15.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.