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ACIN1

GENERAL INFORMATION

Gene name

 ACIN1

Gene description

 Apoptotic chromatin condensation inducer 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA000657
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000657

GENE INFORMATION

Gene name

 ACIN1 (HGNC Symbol)

Synonyms

 ACINUS, fSAP152, KIAA0670

Description

 Apoptotic chromatin condensation inducer 1 (HGNC Symbol)

Entrez gene summary

 Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23058564 - 23095614

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100813 (version 83.38)

Entrez gene

 22985

UniProt

 Q9UKV3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKV3

Antibodypedia

 ACIN1 antibodies

PROTEIN BROWSER
ACIN1-001
ACIN1-002
ACIN1-003
ACIN1-004
ACIN1-006
ACIN1-007
ACIN1-014
ACIN1-022
ACIN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACIN1-001
ENSP00000350073
ENST00000357481
Q9UKV3 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008380 [RNA splicing]
GO:0012501 [programmed cell death]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030263 [apoptotic chromosome condensation]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 583 aa
67.6 kDa 		No 0
ACIN1-002
ENSP00000345541
ENST00000338631
Q9UKV3 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008380 [RNA splicing]
GO:0012501 [programmed cell death]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030263 [apoptotic chromosome condensation]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 614 aa
70.9 kDa 		No 0
ACIN1-003
ENSP00000262710
ENST00000262710
Q9UKV3 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008380 [RNA splicing]
GO:0012501 [programmed cell death]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030263 [apoptotic chromosome condensation]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1341 aa
151.9 kDa 		No 0
ACIN1-004
ENSP00000380502
ENST00000397341
Q9UKV3 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008380 [RNA splicing]
GO:0012501 [programmed cell death]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030263 [apoptotic chromosome condensation]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 583 aa
67.6 kDa 		No 0
ACIN1-006
ENSP00000451328
ENST00000555053
Q9UKV3 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006397 [mRNA processing]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008380 [RNA splicing]
GO:0012501 [programmed cell death]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0030218 [erythrocyte differentiation]
GO:0030263 [apoptotic chromosome condensation]
GO:0035145 [exon-exon junction complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0061574 [ASAP complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1328 aa
150.6 kDa 		No 0
ACIN1-007
ENSP00000451138
ENST00000557515
G3V3B0 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 582 aa
67.5 kDa 		No 0
ACIN1-014
ENSP00000451410
ENST00000555566
G3V3T3 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 194 aa
21.1 kDa 		No 0
ACIN1-022
ENSP00000474349
ENST00000605057
S4R3H4 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 1283 aa
145.4 kDa 		No 0
ACIN1-201
ENSP00000405677
ENST00000457657
E7EQT4 [Direct mapping]
Apoptotic chromatin condensation inducer in the nucleus
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 1301 aa
147.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.