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APEX1

GENERAL INFORMATION

Gene name

 APEX1

Gene description

 APEX nuclease (multifunctional DNA repair enzyme) 1

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA002564 , CAB004294 , CAB047307
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002564
CAB004294
CAB047307

GENE INFORMATION

Gene name

 APEX1 (HGNC Symbol)

Synonyms

 APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1

Description

 APEX nuclease (multifunctional DNA repair enzyme) 1 (HGNC Symbol)

Entrez gene summary

 Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 20455191 - 20457772

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100823 (version 83.38)

Entrez gene

 328

UniProt

 P27695 (UniProt - Evidence at protein level)

neXtProt

 NX_P27695

Antibodypedia

 APEX1 antibodies

PROTEIN BROWSER
«
APEX1-001
APEX1-002
APEX1-003
APEX1-006
APEX1-008
APEX1-009
APEX1-013
APEX1-014
APEX1-016
APEX1-017
APEX1-018
APEX1-019
APEX1-021
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APEX1-001
ENSP00000216714
ENST00000216714
P27695 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
Q5TZP7 [Target identity:100%; Query identity:100%]
APEX nuclease (Multifunctional DNA repair enzyme) 1; APEX nuclease (Multifunctional DNA repair enzyme) 1, isoform CRA_a; Full-length cDNA clone CS0DI036YP02 of Placenta of Homo sapiens (human); cDNA FLJ76713, highly similar to Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2, mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0004521 [endoribonuclease activity]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0005840 [ribosome]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007568 [aging]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0008408 [3'-5' exonuclease activity]
GO:0010243 [response to organonitrogen compound]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016491 [oxidoreductase activity]
GO:0016607 [nuclear speck]
GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base]
GO:0031490 [chromatin DNA binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0032403 [protein complex binding]
GO:0042493 [response to drug]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045454 [cell redox homeostasis]
GO:0045739 [positive regulation of DNA repair]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051059 [NF-kappaB binding]
GO:0055114 [oxidation-reduction process]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071320 [cellular response to cAMP]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071417 [cellular response to organonitrogen compound]
GO:0080111 [DNA demethylation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 318 aa
35.6 kDa 		No 0
APEX1-002
ENSP00000451979
ENST00000555414
P27695 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
Q5TZP7 [Target identity:100%; Query identity:100%]
APEX nuclease (Multifunctional DNA repair enzyme) 1; APEX nuclease (Multifunctional DNA repair enzyme) 1, isoform CRA_a; Full-length cDNA clone CS0DI036YP02 of Placenta of Homo sapiens (human); cDNA FLJ76713, highly similar to Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2, mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0005840 [ribosome]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0008408 [3'-5' exonuclease activity]
GO:0016491 [oxidoreductase activity]
GO:0016607 [nuclear speck]
GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base]
GO:0031490 [chromatin DNA binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045739 [positive regulation of DNA repair]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055114 [oxidation-reduction process]
GO:0080111 [DNA demethylation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 318 aa
35.6 kDa 		No 0
APEX1-003
ENSP00000416414
ENST00000438886
H7C4A8 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 150 aa
16.7 kDa 		No 0
APEX1-006
ENSP00000452212
ENST00000557054
G3V574 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 14 aa
1.5 kDa 		No 0
APEX1-008
ENSP00000381111
ENST00000398030
P27695 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
Q5TZP7 [Target identity:100%; Query identity:100%]
APEX nuclease (Multifunctional DNA repair enzyme) 1; APEX nuclease (Multifunctional DNA repair enzyme) 1, isoform CRA_a; Full-length cDNA clone CS0DI036YP02 of Placenta of Homo sapiens (human); cDNA FLJ76713, highly similar to Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2, mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004844 [uracil DNA N-glycosylase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005813 [centrosome]
GO:0005840 [ribosome]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0008408 [3'-5' exonuclease activity]
GO:0016491 [oxidoreductase activity]
GO:0016607 [nuclear speck]
GO:0016890 [site-specific endodeoxyribonuclease activity, specific for altered base]
GO:0031490 [chromatin DNA binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045739 [positive regulation of DNA repair]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055114 [oxidation-reduction process]
GO:0080111 [DNA demethylation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 318 aa
35.6 kDa 		No 0
APEX1-009
ENSP00000451327
ENST00000553681
G3V3M6 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 263 aa
29.2 kDa 		No 0
APEX1-013
ENSP00000452137
ENST00000557344
A0A0C4DGK8 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 146 aa
15.9 kDa 		No 0
APEX1-014
ENSP00000452304
ENST00000557181
G3V5D9 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 108 aa
11.8 kDa 		No 0
APEX1-016
ENSP00000452460
ENST00000555839
G3V5Q1 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 242 aa
27.1 kDa 		No 0
APEX1-017
ENSP00000451170
ENST00000556054
G3V3C7 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 174 aa
19.1 kDa 		No 0
APEX1-018
ENSP00000451060
ENST00000557592
G3V359 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 172 aa
19.2 kDa 		No 0
APEX1-019
ENSP00000451491
ENST00000553368
G3V3Y6 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 42 aa
4.5 kDa 		No 0
APEX1-021
ENSP00000452418
ENST00000557150
G3V5M0 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 162 aa
17.8 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.