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PABPN1

GENERAL INFORMATION

Gene name

 PABPN1

Gene description

 Poly(A) binding protein, nuclear 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA000637
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PABPN1 (HGNC Symbol)

Synonyms

 OPMD, PAB2, PABP2

Description

 Poly(A) binding protein, nuclear 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23321289 - 23326185

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100836 (version 83.38)

Entrez gene

 8106

UniProt

 Q86U42 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86U42

Antibodypedia

 PABPN1 antibodies

PROTEIN BROWSER
PABPN1-001
PABPN1-003
PABPN1-004
PABPN1-006
PABPN1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PABPN1-001
ENSP00000216727
ENST00000216727
Q86U42 [Direct mapping]
Polyadenylate-binding protein 2
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006396 [RNA processing]
GO:0006936 [muscle contraction]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016973 [poly(A)+ mRNA export from nucleus]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0030529 [ribonucleoprotein complex]
GO:0031124 [mRNA 3'-end processing]
GO:0042405 [nuclear inclusion body]
GO:0044822 [poly(A) RNA binding]
GO:0046778 [modification by virus of host mRNA processing]
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 306 aa
32.7 kDa 		No 0
PABPN1-003
ENSP00000380446
ENST00000397276
Q86U42 [Direct mapping]
Polyadenylate-binding protein 2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006396 [RNA processing]
GO:0006936 [muscle contraction]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016973 [poly(A)+ mRNA export from nucleus]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0030529 [ribonucleoprotein complex]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0046778 [modification by virus of host mRNA processing]
Show all
 296 aa
31.5 kDa 		No 0
PABPN1-004
ENSP00000451970
ENST00000556821
G3V4T2 [Direct mapping]
Polyadenylate-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 178 aa
20.2 kDa 		No 0
PABPN1-006
ENSP00000450724
ENST00000557702
B4DEH8 [Direct mapping]
Polyadenylate-binding protein 2; cDNA FLJ57714, highly similar to Poly(A)-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 168 aa
19 kDa 		No 0
PABPN1-009
ENSP00000451592
ENST00000555295
H0YJH9 [Direct mapping]
Polyadenylate-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 96 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.