Expression of DHRS2 in cancer - Summary

GENERAL INFORMATION
Gene name	DHRS2
Gene description	Dehydrogenase/reductase (SDR family) member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (urothelial cancer)
HPA (cell line):	Cell line enhanced (RT4, SK-BR-3, U-2 OS)
HPA (normal tissue):	Group enriched (breast, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in urothelial cells as well as ductal cells in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA069551
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA069551

GENE INFORMATION
Gene name	DHRS2 (HGNC Symbol)
Synonyms	HEP27, SDR25C1
Description	Dehydrogenase/reductase (SDR family) member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23630115 - 23645639
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100867 (version 83.38)
Entrez gene	10202
UniProt	Q13268 (UniProt - Evidence at protein level)
neXtProt	NX_Q13268
Antibodypedia	DHRS2 antibodies

PROTEIN BROWSER

DHRS2-001	DHRS2-002	DHRS2-003	DHRS2-008	DHRS2-009	DHRS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHRS2-001 ENSP00000250383 ENST00000250383	Q13268 [Direct mapping] Dehydrogenase/reductase SDR family member 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004090 [carbonyl reductase (NADPH) activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008207 [C21-steroid hormone metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0016491 [oxidoreductase activity] GO:0034599 [cellular response to oxidative stress] GO:0043011 [myeloid dendritic cell differentiation] GO:0043066 [negative regulation of apoptotic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	280 aa 29.9 kDa	No	0
DHRS2-002 ENSP00000344674 ENST00000344777	Q13268 [Direct mapping] Dehydrogenase/reductase SDR family member 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004090 [carbonyl reductase (NADPH) activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0008207 [C21-steroid hormone metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0016491 [oxidoreductase activity] GO:0034599 [cellular response to oxidative stress] GO:0043011 [myeloid dendritic cell differentiation] GO:0043066 [negative regulation of apoptotic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	300 aa 31.5 kDa	No	0
DHRS2-003 ENSP00000401213 ENST00000432832	C9JZP6 [Direct mapping] Dehydrogenase/reductase SDR family member 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	225 aa 23.8 kDa	No	0
DHRS2-008 ENSP00000451895 ENST00000557535	H0YJP4 [Direct mapping] Dehydrogenase/reductase SDR family member 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	180 aa 19.2 kDa	No	0
DHRS2-009 ENSP00000451485 ENST00000553600	H0YJG9 [Direct mapping] Dehydrogenase/reductase SDR family member 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	161 aa 17.5 kDa	No	0
DHRS2-201 ENSP00000481607 ENST00000611765	Q13268 [Direct mapping] Dehydrogenase/reductase SDR family member 2, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004090 [carbonyl reductase (NADPH) activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0008207 [C21-steroid hormone metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0016491 [oxidoreductase activity] GO:0034599 [cellular response to oxidative stress] GO:0043011 [myeloid dendritic cell differentiation] GO:0043066 [negative regulation of apoptotic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	300 aa 31.5 kDa	No	0