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SRP54

GENERAL INFORMATION

Gene name

 SRP54

Gene description

 Signal recognition particle 54kDa

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA048977
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048977

GENE INFORMATION

Gene name

 SRP54

Synonyms

Description

 Signal recognition particle 54kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q13.2

Chromosome location (bp)

 34981957 - 35029567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100883 (version 83.38)

Entrez gene

 6729

UniProt

 P61011 (UniProt - Evidence at protein level)

neXtProt

 NX_P61011

Antibodypedia

 SRP54 antibodies

PROTEIN BROWSER
SRP54-001
SRP54-002
SRP54-005
SRP54-006
SRP54-201
SRP54-202
SRP54-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRP54-001
ENSP00000451818
ENST00000556994
P61011 [Direct mapping]
Signal recognition particle 54 kDa protein
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation]
GO:0006617 [SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition]
GO:0008144 [drug binding]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0019003 [GDP binding]
GO:0030942 [endoplasmic reticulum signal peptide binding]
GO:0042493 [response to drug]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045047 [protein targeting to ER]
GO:0048500 [signal recognition particle]
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 504 aa
55.7 kDa 		No 0
SRP54-002
ENSP00000451775
ENST00000555557
G3V4F7 [Direct mapping]
Signal recognition particle 54 kDa protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008152 [metabolic process]
GO:0008312 [7S RNA binding]
GO:0048500 [signal recognition particle]
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 440 aa
48.7 kDa 		No 0
SRP54-005
ENSP00000451037
ENST00000554803
G3V346 [Direct mapping]
Signal recognition particle 54 kDa protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
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 44 aa
4.7 kDa 		No 0
SRP54-006
ENSP00000451647
ENST00000555746
G3V480 [Direct mapping]
Signal recognition particle 54 kDa protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
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 74 aa
8.2 kDa 		No 0
SRP54-201
ENSP00000216774
ENST00000216774
P61011 [Direct mapping]
Signal recognition particle 54 kDa protein
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation]
GO:0006617 [SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition]
GO:0008144 [drug binding]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0019003 [GDP binding]
GO:0030942 [endoplasmic reticulum signal peptide binding]
GO:0042493 [response to drug]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045047 [protein targeting to ER]
GO:0048500 [signal recognition particle]
Show all
 504 aa
55.7 kDa 		No 0
SRP54-202
ENSP00000440629
ENST00000546080
P61011 [Direct mapping]
Signal recognition particle 54 kDa protein
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation]
GO:0006617 [SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition]
GO:0008144 [drug binding]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0019003 [GDP binding]
GO:0030942 [endoplasmic reticulum signal peptide binding]
GO:0042493 [response to drug]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045047 [protein targeting to ER]
GO:0048500 [signal recognition particle]
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 455 aa
50.4 kDa 		No 0
SRP54-203
ENSP00000486764
ENST00000630962
A0A0D9SFN7 [Direct mapping]
Signal recognition particle 54 kDa protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
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 53 aa
5.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.