Expression of PCK2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PCK2
Gene description	Phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Protein class	Citric acid cycle related proteins Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Group enriched (duodenum, kidney, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct granular cytoplasmic expression, mainly in the small intestine, hepatocytes and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA051162 , HPA053502 , CAB018734
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA051162	HPA053502	CAB018734

GENE INFORMATION
Gene name	PCK2 (HGNC Symbol)
Synonyms	PEPCK, PEPCK2
Description	Phosphoenolpyruvate carboxykinase 2 (mitochondrial) (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Chromosome	14
Cytoband
Chromosome location (bp)	24094053 - 24110598
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100889 (version 83.38)
Entrez gene	5106
UniProt	Q16822 (UniProt - Evidence at protein level)
neXtProt	NX_Q16822
Antibodypedia	PCK2 antibodies

PROTEIN BROWSER

PCK2-001	PCK2-002	PCK2-003	PCK2-005	PCK2-007	PCK2-008	PCK2-009	PCK2-012	PCK2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCK2-001 ENSP00000380171 ENST00000396973	A0A0A0MS74 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0004613 [phosphoenolpyruvate carboxykinase (GTP) activity] GO:0005525 [GTP binding] GO:0006094 [gluconeogenesis] GO:0017076 [purine nucleotide binding] Show all	441 aa 47.5 kDa	No	0
PCK2-002 ENSP00000216780 ENST00000216780	Q16822 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0004613 [phosphoenolpyruvate carboxykinase (GTP) activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0017076 [purine nucleotide binding] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	640 aa 70.7 kDa	No	0
PCK2-003 ENSP00000453444 ENST00000559250	H0YM31 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0004613 [phosphoenolpyruvate carboxykinase (GTP) activity] GO:0005525 [GTP binding] GO:0005739 [mitochondrion] GO:0006094 [gluconeogenesis] GO:0017076 [purine nucleotide binding] Show all	509 aa 54.6 kDa	No	0
PCK2-005 ENSP00000454011 ENST00000561286	B4DW73 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32); cDNA, FLJ79105, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32) Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0004613 [phosphoenolpyruvate carboxykinase (GTP) activity] GO:0005525 [GTP binding] GO:0006094 [gluconeogenesis] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0017076 [purine nucleotide binding] Show all	506 aa 56 kDa	No	0
PCK2-007 ENSP00000453656 ENST00000558096	H0YML5 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0004613 [phosphoenolpyruvate carboxykinase (GTP) activity] GO:0005525 [GTP binding] GO:0006094 [gluconeogenesis] GO:0017076 [purine nucleotide binding] Show all	474 aa 52.5 kDa	No	0
PCK2-008 ENSP00000441826 ENST00000545054	B4DW73 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32); cDNA, FLJ79105, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32) Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0004613 [phosphoenolpyruvate carboxykinase (GTP) activity] GO:0005525 [GTP binding] GO:0006094 [gluconeogenesis] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0017076 [purine nucleotide binding] Show all	506 aa 56 kDa	No	0
PCK2-009 ENSP00000453791 ENST00000559171	H0YMY3 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0005525 [GTP binding] GO:0006094 [gluconeogenesis] Show all	109 aa 11.9 kDa	No	0
PCK2-012 ENSP00000453998 ENST00000560736	H0YNG4 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0005525 [GTP binding] GO:0006094 [gluconeogenesis] GO:0017076 [purine nucleotide binding] Show all	113 aa 12.3 kDa	No	0
PCK2-013 ENSP00000453751 ENST00000559837	H0YMU6 [Direct mapping] Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004611 [phosphoenolpyruvate carboxykinase activity] GO:0005525 [GTP binding] GO:0006094 [gluconeogenesis] GO:0017076 [purine nucleotide binding] Show all	107 aa 11.5 kDa	No	0