Expression of GMPR2 in cancer - Summary

GENERAL INFORMATION
Gene name	GMPR2
Gene description	Guanosine monophosphate reductase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	21
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA000904
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000904

GENE INFORMATION
Gene name	GMPR2
Synonyms
Description	Guanosine monophosphate reductase 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24232422 - 24239242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100938 (version 83.38)
Entrez gene	51292
UniProt	Q9P2T1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2T1
Antibodypedia	GMPR2 antibodies

PROTEIN BROWSER

GMPR2-001	GMPR2-002	GMPR2-003	GMPR2-004	GMPR2-007	GMPR2-009	GMPR2-010	GMPR2-011	GMPR2-012	GMPR2-017	GMPR2-018	GMPR2-019	GMPR2-020	GMPR2-021	GMPR2-022	GMPR2-023	GMPR2-024	GMPR2-026	GMPR2-029	GMPR2-201	GMPR2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GMPR2-001 ENSP00000392859 ENST00000420554	Q9P2T1 [Direct mapping] GMP reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	366 aa 39.8 kDa	No	0
GMPR2-002 ENSP00000453299 ENST00000559836	Q9P2T1 [Direct mapping] GMP reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	348 aa 37.9 kDa	No	0
GMPR2-003 ENSP00000347449 ENST00000355299	Q9P2T1 [Direct mapping] GMP reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	348 aa 37.9 kDa	No	0
GMPR2-004 ENSP00000382369 ENST00000399440	Q9P2T1 [Direct mapping] GMP reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	348 aa 37.9 kDa	No	0
GMPR2-007 ENSP00000453537 ENST00000559910	H0YMB3 [Direct mapping] GMP reductase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	315 aa 33.9 kDa	No	0
GMPR2-009 ENSP00000454038 ENST00000557854	H0YNJ6 [Direct mapping] GMP reductase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	427 aa 46.9 kDa	No	0
GMPR2-010 ENSP00000453355 ENST00000559104	H0YLV5 [Direct mapping] GMP reductase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	333 aa 35.9 kDa	No	0
GMPR2-011 ENSP00000405743 ENST00000456667	Q9P2T1 [Direct mapping] GMP reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046037 [GMP metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	320 aa 34.6 kDa	No	0
GMPR2-012 ENSP00000453714 ENST00000560139	H0YMR9 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0055114 [oxidation-reduction process] Show all	132 aa 14.7 kDa	No	0
GMPR2-017 ENSP00000453139 ENST00000558483	H0YLB8 [Direct mapping] GMP reductase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	169 aa 18 kDa	No	0
GMPR2-018 ENSP00000452766 ENST00000559943	H0YKE1 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0055114 [oxidation-reduction process] Show all	64 aa 6.8 kDa	No	0
GMPR2-019 ENSP00000452683 ENST00000558748	H0YK71 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0055114 [oxidation-reduction process] Show all	139 aa 15 kDa	No	0
GMPR2-020 ENSP00000452617 ENST00000559479	H0YK13 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0055114 [oxidation-reduction process] Show all	88 aa 9.7 kDa	No	0
GMPR2-021 ENSP00000453772 ENST00000558788	H0YMW6 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0055114 [oxidation-reduction process] Show all	93 aa 10.1 kDa	No	0
GMPR2-022 ENSP00000453833 ENST00000558932	H0YN22 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0055114 [oxidation-reduction process] Show all	69 aa 7.5 kDa	No	0
GMPR2-023 ENSP00000454138 ENST00000558865	H0YNS9 [Direct mapping] GMP reductase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	126 aa 12.9 kDa	No	0
GMPR2-024 ENSP00000453079 ENST00000558279	H0YL68 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	57 aa 6.3 kDa	No	0
GMPR2-026 ENSP00000454009 ENST00000561035	H0YNH0 [Direct mapping] GMP reductase 2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	240 aa 26.8 kDa	No	0
GMPR2-029 ENSP00000453761 ENST00000559409	H0YMV5 [Direct mapping] GMP reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0055114 [oxidation-reduction process] Show all	151 aa 17.2 kDa	No	0
GMPR2-201 ENSP00000334409 ENST00000348719	F8WAN9 [Direct mapping] GMP reductase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	349 aa 38.3 kDa	No	0
GMPR2-202 ENSP00000480342 ENST00000620807	A0A087WWM4 [Direct mapping] GMP reductase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003920 [GMP reductase activity] GO:0009117 [nucleotide metabolic process] GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:1902560 [GMP reductase complex] Show all	348 aa 38.2 kDa	No	0