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Several colorectal cancer and a few melanomas, lung, liver and pancreatic cancers were moderately stained. Remaining cancer tissues were in general weakly stained or negative.
Weak to moderate nuclear and cytoplasmic positivity was seen in most malignant cells. Several cases of lung and colorectal cancers and a few cases of skin cancers were strongly stained. Several cases of carcinoids, hepatocellular carcinomas, stomach and pancreatic cancers were negative.
GENE INFORMATION
Gene name
NFATC4 (HGNC Symbol)
Synonyms
NFAT3
Description
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
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Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001569 [patterning of blood vessels] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0033173 [calcineurin-NFAT signaling cascade] GO:0034644 [cellular response to UV] GO:0035562 [negative regulation of chromatin binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043065 [positive regulation of apoptotic process] GO:0045111 [intermediate filament cytoskeleton] GO:0045333 [cellular respiration] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048167 [regulation of synaptic plasticity] GO:0050774 [negative regulation of dendrite morphogenesis] GO:0051145 [smooth muscle cell differentiation] GO:0055001 [muscle cell development] GO:0071285 [cellular response to lithium ion] GO:2000297 [negative regulation of synapse maturation] GO:2001235 [positive regulation of apoptotic signaling pathway]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]