Expression of GINS1 in cancer - Summary - The Human Protein Atlas

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GINS1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GINS1
Gene description	GINS complex subunit 1 (Psf1 homolog)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA051185
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051185

GENE INFORMATION
Gene name	GINS1 (HGNC Symbol)
Synonyms	KIAA0186, PSF1
Description	GINS complex subunit 1 (Psf1 homolog) (HGNC Symbol)
Entrez gene summary	The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	25407727 - 25452628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101003 (version 83.38)
Entrez gene	9837
UniProt	Q14691 (UniProt - Evidence at protein level)
neXtProt	NX_Q14691
Antibodypedia	GINS1 antibodies

PROTEIN BROWSER

GINS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GINS1-001 ENSP00000262460 ENST00000262460	Q14691 [Direct mapping] DNA replication complex GINS protein PSF1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0001833 [inner cell mass cell proliferation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006271 [DNA strand elongation involved in DNA replication] Show all	196 aa 23 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.