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RNA cell line category: Cell line enhanced (EFO-21, CAPAN-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
CD40 (HGNC Symbol)
Synonyms
Bp50, p50, TNFRSF5
Description
CD40 molecule, TNF receptor superfamily member 5 (HGNC Symbol)
Entrez gene summary
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
P25942 [Direct mapping] Tumor necrosis factor receptor superfamily member 5
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CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0004871 [signal transducer activity] GO:0004872 [receptor activity] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006874 [cellular calcium ion homeostasis] GO:0007275 [multicellular organismal development] GO:0009986 [cell surface] GO:0019899 [enzyme binding] GO:0030168 [platelet activation] GO:0031625 [ubiquitin protein ligase binding] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035631 [CD40 receptor complex] GO:0042100 [B cell proliferation] GO:0042127 [regulation of cell proliferation] GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043406 [positive regulation of MAP kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050776 [regulation of immune response] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070062 [extracellular exosome] GO:0071260 [cellular response to mechanical stimulus] GO:0090037 [positive regulation of protein kinase C signaling] GO:0097190 [apoptotic signaling pathway] GO:2000353 [positive regulation of endothelial cell apoptotic process]
