Expression of IFT52 in cancer - Summary

GENERAL INFORMATION
Gene name	IFT52
Gene description	Intraflagellar transport 52
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, highest expresssion in ciliated cells in fallopian tube and bronchus.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA067423
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and testis cancer (favourable).
Liver cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA067423

GENE INFORMATION
Gene name	IFT52 (HGNC Symbol)
Synonyms	C20orf9, CGI-53, dJ1028D15.1, NGD2, NGD5
Description	Intraflagellar transport 52 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	43590931 - 43647296
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101052 (version 83.38)
Entrez gene	51098
UniProt	Q9Y366 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y366
Antibodypedia	IFT52 antibodies

PROTEIN BROWSER

IFT52-001	IFT52-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFT52-001 ENSP00000362121 ENST00000373030	Q9Y366 [Direct mapping] Intraflagellar transport protein 52 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001841 [neural tube formation] GO:0001947 [heart looping] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005929 [cilium] GO:0006996 [organelle organization] GO:0007224 [smoothened signaling pathway] GO:0007368 [determination of left/right symmetry] GO:0008022 [protein C-terminus binding] GO:0009953 [dorsal/ventral pattern formation] GO:0030992 [intraciliary transport particle B] GO:0031514 [motile cilium] GO:0032391 [photoreceptor connecting cilium] GO:0042073 [intraciliary transport] GO:0042733 [embryonic digit morphogenesis] GO:0044292 [dendrite terminus] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0060271 [cilium morphogenesis] GO:0070613 [regulation of protein processing] GO:0072372 [primary cilium] GO:0097542 [ciliary tip] GO:0097546 [ciliary base] Show all	437 aa 49.7 kDa	No	0
IFT52-002 ENSP00000362130 ENST00000373039	Q9Y366 [Direct mapping] Intraflagellar transport protein 52 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005814 [centriole] GO:0006996 [organelle organization] GO:0008022 [protein C-terminus binding] GO:0030992 [intraciliary transport particle B] GO:0031514 [motile cilium] GO:0042073 [intraciliary transport] GO:0060271 [cilium morphogenesis] GO:0072372 [primary cilium] GO:0097542 [ciliary tip] Show all	437 aa 49.7 kDa	No	0