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RAE1

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GENERAL INFORMATION

Gene name

 RAE1

Gene description

 Ribonucleic acid export 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (supported)

Additional location

 In addition localized to the Nucleus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA048795
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.

Main location

 Nucleoli fibrillar center (supported)

Additional location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA048795 CACO-2 Nucleoli fibrillar center
HPA048795 PC-3 Nucleus
Nucleoli fibrillar center
HPA048795 U-2 OS Nucleus
Nucleoli fibrillar center

GENE INFORMATION

Gene name

 RAE1 (HGNC Symbol)

Synonyms

 Mnrp41

Description

 Ribonucleic acid export 1 (HGNC Symbol)

Entrez gene summary

 Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.31

Chromosome location (bp)

 57351010 - 57379211

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101146 (version 83.38)

Entrez gene

 8480

UniProt

 P78406 (UniProt - Evidence at protein level)

neXtProt

 NX_P78406

Antibodypedia

 RAE1 antibodies

PROTEIN BROWSER
RAE1-001
RAE1-002
RAE1-003
RAE1-005
RAE1-006
RAE1-007
RAE1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAE1-001
ENSP00000379182
ENST00000395841
P78406 [Direct mapping]
mRNA export factor
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005643 [nuclear pore]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005975 [carbohydrate metabolic process]
GO:0006406 [mRNA export from nucleus]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008017 [microtubule binding]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0071407 [cellular response to organic cyclic compound]
GO:1900034 [regulation of cellular response to heat]
Show all
 368 aa
41 kDa 		No 0
RAE1-002
ENSP00000360286
ENST00000371242
P78406 [Direct mapping]
mRNA export factor
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005643 [nuclear pore]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005975 [carbohydrate metabolic process]
GO:0006406 [mRNA export from nucleus]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008017 [microtubule binding]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 368 aa
41 kDa 		No 0
RAE1-003
ENSP00000379181
ENST00000395840
P78406 [Direct mapping]
mRNA export factor
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005643 [nuclear pore]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005975 [carbohydrate metabolic process]
GO:0006406 [mRNA export from nucleus]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008017 [microtubule binding]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 368 aa
41 kDa 		No 0
RAE1-005
ENSP00000402924
ENST00000452119
B0QZ37 [Direct mapping]
mRNA export factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 87 aa
9.2 kDa 		No 0
RAE1-006
ENSP00000392097
ENST00000411894
B0QZ36 [Direct mapping]
mRNA export factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 137 aa
14.7 kDa 		No 0
RAE1-007
ENSP00000393264
ENST00000429339
B0QZ36 [Direct mapping]
mRNA export factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 137 aa
14.7 kDa 		No 0
RAE1-010
ENSP00000432609
ENST00000527947
E9PQ57 [Direct mapping]
mRNA export factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 437 aa
47.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.