Expression of CTSZ in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CTSZ
Gene description	Cathepsin Z
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in many cell types, highest expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA049876 , HPA053504 , CAB025114
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA049876	HPA053504	CAB025114

GENE INFORMATION
Gene name	CTSZ (HGNC Symbol)
Synonyms	CTSX
Description	Cathepsin Z (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
Chromosome	20
Cytoband	q13.32
Chromosome location (bp)	58995185 - 59007247
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101160 (version 83.38)
Entrez gene	1522
UniProt	Q9UBR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBR2
Antibodypedia	CTSZ antibodies

PROTEIN BROWSER

CTSZ-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTSZ-001 ENSP00000217131 ENST00000217131	Q9UBR2 [Direct mapping] Cathepsin Z Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002003 [angiotensin maturation] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008234 [cysteine-type peptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	303 aa 33.9 kDa	Yes	0