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Malignant cells displayed moderate to strong nuclear staining. Several squamous cell carcinomas of skin, renal, prostate and endometrial cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PRPF6 (HGNC Symbol)
Synonyms
ANT-1, bB152O15.1, C20orf14, hPrp6, Prp6, RP60, SNRNP102, TOM, U5-102K
Description
Pre-mRNA processing factor 6 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]
Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)