Tissue expression of HRH3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HRH3
Gene description	Histamine receptor H3
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:	Tissue enhanced (caudate, cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, cerebellum)

GENE INFORMATION
Gene name	HRH3 (HGNC Symbol)
Synonyms	GPCR97
Description	Histamine receptor H3 (HGNC Symbol)
Entrez gene summary	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	62214970 - 62220267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101180 (version 83.38)
Entrez gene	11255
UniProt	Q9Y5N1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5N1
Antibodypedia	HRH3 antibodies

PROTEIN BROWSER

HRH3-001	HRH3-201	HRH3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRH3-001 ENSP00000342560 ENST00000340177	Q9Y5N1 [Direct mapping] Histamine H3 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007269 [neurotransmitter secretion] GO:0007606 [sensory perception of chemical stimulus] GO:0014050 [negative regulation of glutamate secretion] GO:0014061 [regulation of norepinephrine secretion] GO:0014063 [negative regulation of serotonin secretion] GO:0016021 [integral component of membrane] GO:0050890 [cognition] GO:0051381 [histamine binding] Show all	445 aa 48.7 kDa	No	7
HRH3-201 ENSP00000321482 ENST00000317393	A0A0A0MR48 [Direct mapping] Histamine H3 receptor; Histamine receptor H3, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001505 [regulation of neurotransmitter levels] GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007606 [sensory perception of chemical stimulus] GO:0014050 [negative regulation of glutamate secretion] GO:0014061 [regulation of norepinephrine secretion] GO:0014063 [negative regulation of serotonin secretion] GO:0016021 [integral component of membrane] GO:0050890 [cognition] GO:0051381 [histamine binding] Show all	373 aa 41.6 kDa	No	7
HRH3-202 ENSP00000482567 ENST00000611492	A0A087WZD3 [Direct mapping] Histamine H3 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0001505 [regulation of neurotransmitter levels] GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007606 [sensory perception of chemical stimulus] GO:0014050 [negative regulation of glutamate secretion] GO:0014061 [regulation of norepinephrine secretion] GO:0014063 [negative regulation of serotonin secretion] GO:0016021 [integral component of membrane] GO:0050890 [cognition] GO:0051381 [histamine binding] Show all	200 aa 21.6 kDa	No	4