Expression of SLCO4A1 in cancer - Summary - The Human Protein Atlas

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SLCO4A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLCO4A1
Gene description	Solute carrier organic anion transporter family, member 4A1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (PC-3, RPTEC TERT1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA030669 , HPA030670
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030669	HPA030670

GENE INFORMATION
Gene name	SLCO4A1 (HGNC Symbol)
Synonyms	OATP-E, OATP4A1, SLC21A12
Description	Solute carrier organic anion transporter family, member 4A1 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	62642445 - 62685785
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101187 (version 83.38)
Entrez gene	28231
UniProt	Q96BD0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BD0
Antibodypedia	SLCO4A1 antibodies

PROTEIN BROWSER

SLCO4A1-006	SLCO4A1-007	SLCO4A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLCO4A1-006 ENSP00000359538 ENST00000370507	Q96BD0 [Direct mapping] Solute carrier organic anion transporter family member 4A1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015349 [thyroid hormone transmembrane transporter activity] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070327 [thyroid hormone transport] GO:0098656 [anion transmembrane transport] Show all	722 aa 77.2 kDa	No	>9
SLCO4A1-007 ENSP00000414855 ENST00000451793	A0A0A0MT51 [Direct mapping] Solute carrier organic anion transporter family member 4A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	151 aa 16.5 kDa	No	2
SLCO4A1-201 ENSP00000217159 ENST00000217159	Q96BD0 [Direct mapping] Solute carrier organic anion transporter family member 4A1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015349 [thyroid hormone transmembrane transporter activity] GO:0016020 [membrane] GO:0042403 [thyroid hormone metabolic process] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070327 [thyroid hormone transport] GO:0098656 [anion transmembrane transport] Show all	722 aa 77.2 kDa	No	>9

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The Human Protein Atlas

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