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ARFGAP1

GENERAL INFORMATION

Gene name

 ARFGAP1

Gene description

 ADP-ribosylation factor GTPase activating protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA051019 , HPA056273
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051019
HPA056273

GENE INFORMATION

Gene name

 ARFGAP1 (HGNC Symbol)

Synonyms

 ARF1GAP, bA261N11.3, FLJ10767

Description

 ADP-ribosylation factor GTPase activating protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63272785 - 63289793

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101199 (version 83.38)

Entrez gene

 55738

UniProt

 Q8N6T3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N6T3

Antibodypedia

 ARFGAP1 antibodies

PROTEIN BROWSER
«
ARFGAP1-001
ARFGAP1-003
ARFGAP1-004
ARFGAP1-006
ARFGAP1-007
ARFGAP1-010
ARFGAP1-012
ARFGAP1-015
ARFGAP1-016
ARFGAP1-021
ARFGAP1-023
ARFGAP1-201
ARFGAP1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARFGAP1-001
ENSP00000359306
ENST00000370283
Q8N6T3 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0015031 [protein transport]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043547 [positive regulation of GTPase activity]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
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 406 aa
44.7 kDa 		No 0
ARFGAP1-003
ENSP00000314615
ENST00000353546
Q8N6T3 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0015031 [protein transport]
GO:0030100 [regulation of endocytosis]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043547 [positive regulation of GTPase activity]
GO:0044267 [cellular protein metabolic process]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
GO:0097481 [neuronal postsynaptic density]
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 414 aa
45.7 kDa 		No 0
ARFGAP1-004
ENSP00000359298
ENST00000370275
Q8N6T3 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0015031 [protein transport]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043547 [positive regulation of GTPase activity]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
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 403 aa
44.5 kDa 		No 0
ARFGAP1-006
ENSP00000449515
ENST00000550188
F8VWB3 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
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 122 aa
14.1 kDa 		No 0
ARFGAP1-007
ENSP00000449800
ENST00000547204
F8VWH9 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 340 aa
37.1 kDa 		No 0
ARFGAP1-010
ENSP00000428355
ENST00000523114
E5RIU2 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
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 79 aa
9 kDa 		No 0
ARFGAP1-012
ENSP00000429770
ENST00000523460
E5RHH7 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 153 aa
16.4 kDa 		No 0
ARFGAP1-015
ENSP00000430929
ENST00000522403
E5RHC5 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
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 261 aa
29.1 kDa 		No 0
ARFGAP1-016
ENSP00000429674
ENST00000518601
E5RHT6 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 244 aa
26.6 kDa 		No 0
ARFGAP1-021
ENSP00000447037
ENST00000549047
F8W1U7 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 271 aa
29.6 kDa 		No 0
ARFGAP1-023
ENSP00000449849
ENST00000549076
H0YIQ0 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 104 aa
11.1 kDa 		No 0
ARFGAP1-201
ENSP00000443716
ENST00000519273
Q8N6T3 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0015031 [protein transport]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043547 [positive regulation of GTPase activity]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
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 293 aa
31.5 kDa 		No 0
ARFGAP1-202
ENSP00000430500
ENST00000519604
Q8N6T3 [Direct mapping]
ADP-ribosylation factor GTPase-activating protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0015031 [protein transport]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0043547 [positive regulation of GTPase activity]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
Show all
 361 aa
39.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.