Fields »
ABOUT
HELP
BLOG
CHRNA4

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CHRNA4

Gene description

 Cholinergic receptor, nicotinic, alpha 4 (neuronal)

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CHRNA4 (HGNC Symbol)

Synonyms

 BFNC, EBN, EBN1

Description

 Cholinergic receptor, nicotinic, alpha 4 (neuronal) (HGNC Symbol)

Entrez gene summary

 This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63343223 - 63378401

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101204 (version 83.38)

Entrez gene

 1137

UniProt

 P43681 (UniProt - Evidence at protein level)

neXtProt

 NX_P43681

Antibodypedia

 CHRNA4 antibodies

PROTEIN BROWSER
CHRNA4-001
CHRNA4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNA4-001
ENSP00000359285
ENST00000370263
P43681 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001508 [action potential]
GO:0001666 [response to hypoxia]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005216 [ion channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006281 [DNA repair]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0007585 [respiratory gaseous exchange]
GO:0007626 [locomotory behavior]
GO:0009897 [external side of plasma membrane]
GO:0014059 [regulation of dopamine secretion]
GO:0015276 [ligand-gated ion channel activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035094 [response to nicotine]
GO:0035095 [behavioral response to nicotine]
GO:0035640 [exploration behavior]
GO:0042113 [B cell activation]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0050890 [cognition]
GO:0051899 [membrane depolarization]
GO:0060080 [inhibitory postsynaptic potential]
GO:0098655 [cation transmembrane transport]
Show all
 627 aa
70 kDa 		Yes 4
CHRNA4-201
ENSP00000483388
ENST00000615287
P43681 [Direct mapping]
Neuronal acetylcholine receptor subunit alpha-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001508 [action potential]
GO:0001666 [response to hypoxia]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006281 [DNA repair]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0009897 [external side of plasma membrane]
GO:0014059 [regulation of dopamine secretion]
GO:0015276 [ligand-gated ion channel activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035094 [response to nicotine]
GO:0035095 [behavioral response to nicotine]
GO:0042113 [B cell activation]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0050890 [cognition]
GO:0051899 [membrane depolarization]
GO:0060080 [inhibitory postsynaptic potential]
GO:0098655 [cation transmembrane transport]
Show all
 556 aa
61 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.