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EEF1A2

GENERAL INFORMATION

Gene name

 EEF1A2

Gene description

 Eukaryotic translation elongation factor 1 alpha 2

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (MCF7, SCLC-21H, T-47d, U-2 OS)
HPA (normal tissue):Group enriched (cerebral cortex, heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in neuronal cells and skeletal myocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA051759 , HPA056990 , CAB034019
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and head and neck cancer (unfavourable).
Endometrial cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051759
HPA056990
CAB034019

GENE INFORMATION

Gene name

 EEF1A2 (HGNC Symbol)

Synonyms

 EEF1AL, HS1, STN, STNL

Description

 Eukaryotic translation elongation factor 1 alpha 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63488013 - 63499315

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101210 (version 83.38)

Entrez gene

 1917

UniProt

 Q05639 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05639

Antibodypedia

 EEF1A2 antibodies

PROTEIN BROWSER
EEF1A2-001
EEF1A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EEF1A2-001
ENSP00000298049
ENST00000298049
Q05639 [Direct mapping]
Elongation factor 1-alpha 2
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0006414 [translational elongation]
GO:0008135 [translation factor activity, RNA binding]
GO:0019901 [protein kinase binding]
GO:0090218 [positive regulation of lipid kinase activity]
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 463 aa
50.5 kDa 		No 0
EEF1A2-201
ENSP00000217182
ENST00000217182
Q05639 [Direct mapping]
Elongation factor 1-alpha 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006414 [translational elongation]
GO:0008135 [translation factor activity, RNA binding]
GO:0010035 [response to inorganic substance]
GO:0019901 [protein kinase binding]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043209 [myelin sheath]
GO:0051602 [response to electrical stimulus]
GO:0090218 [positive regulation of lipid kinase activity]
Show all
 463 aa
50.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.