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GMEB2

GENERAL INFORMATION

Gene name

 GMEB2

Gene description

 Glucocorticoid modulatory element binding protein 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA009706
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA009706

GENE INFORMATION

Gene name

 GMEB2 (HGNC Symbol)

Synonyms

 KIAA1269, P79PIF, PIF79

Description

 Glucocorticoid modulatory element binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63587602 - 63627041

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101216 (version 83.38)

Entrez gene

 26205

UniProt

 Q9UKD1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKD1

Antibodypedia

 GMEB2 antibodies

PROTEIN BROWSER
GMEB2-001
GMEB2-002
GMEB2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMEB2-001
ENSP00000266068
ENST00000266068
Q9UKD1 [Direct mapping]
Glucocorticoid modulatory element-binding protein 2
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Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 530 aa
56.4 kDa 		No 0
GMEB2-002
ENSP00000359086
ENST00000370069
Q5JTV1 [Direct mapping]
Glucocorticoid modulatory element binding protein 2, isoform CRA_a; Glucocorticoid modulatory element-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:1903506 [regulation of nucleic acid-templated transcription]
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 479 aa
51.2 kDa 		No 0
GMEB2-003
ENSP00000359094
ENST00000370077
Q9UKD1 [Direct mapping]
Glucocorticoid modulatory element-binding protein 2
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Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 530 aa
56.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.